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- W2344141964 abstract "Combination PDT (cPDT) involving preconditioning with a differentiation-promoting agent prior to aminolevulinate (ALA)-PDT, is a new and promising approach for the treatment of non-melanoma skin cancers. We previously reported a cPDT approach using the active form of vitamin D3 (calcitriol) given systemically prior to PDT, which resulted in elevated protoporphyrin (PpIX) accumulation and PDT-induced cell death in A431 murine SCC tumors. However, since calcitriol may pose a risk for hypercalcemia in humans, we replaced calcitriol with natural dietary vitamin D3 (D3; cholecalciferol; 10-fold; 10K) fed over a 10-day period. In this study, we ask whether vitamin D3 deficiency may alter the response to cPDT. Nude mice were fed with a D3 deficient diet for 4 weeks while control mice were fed the normal diet. Human A431 SCC cells were then implanted subcutaneously and mice were either switched to a 10K diet or given a human equivalent dose of 50,000 IU D3 by oral gavage to simulate treatments with high dose D3 pills. At different times during the cPDT regimen, tumors and tissues including skin and serum (to measure vitamin D3 metabolic intermediates) were collected for analyses. Following D3 supplementation, a tumor-selective increase in the levels of PpIX and in expression of markers of differentiation (E-Cadherin) and proliferation Ki67 were observed in both the D3-deficient and the normal control mice. Serum levels of D3 and its metabolic intermediates (25-OH-vitamin D3 and 1, 25a-(OH)2-vitamin D3) and expression levels of heme- and vitamin D3-metabolic enzymes in tumors, skin, and other tissues were also analyzed. These results suggest that a clinical study using oral vitamin D3 prior to ALA-PDT, should be considered to evaluate a new promising approach for the treatment of human skin cancer." @default.
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- W2344141964 date "2016-05-01" @default.
- W2344141964 modified "2023-09-27" @default.
- W2344141964 title "595 Oral vitamin D 3 supplementation for combination photodynamic therapy (cPDT) in vitamin D 3 deficient populations: A preclinical study with implications for an improved therapeutic response" @default.
- W2344141964 doi "https://doi.org/10.1016/j.jid.2016.02.634" @default.
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