FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344144712> ?p ?o ?g. }

• W2344144712 abstract "Hepatitis B virus (HBV) is accounting for over one million deaths annually due to immune-mediated chronic liver damage. Natural killer (NK) cells are abundant in the liver and contribute in HBV persistence. NK cytotoxic effects are controlled by signals from activating and inhibitory receptors. HBV may circumvent host antiviral immunity via the regulation of NK receptors and their ligands. We investigated the effect of viral replication and HBeAg mutations on NK mediators expression in the livers of chronic HBV (CHB) patients and in cell cultures.HBV monomers bearing hotspot mutations in the basal core promoter and precore region were transfected into HepG2 cells using a plasmid-free assay. Serum viremia and liver HBV RNA were measured in 19 CHB patients. The expression of HBV RNA and of NKG2D ligands, B7H6, DNAX accessory molecule-1, lectin-like transcript 1 (LLT1), LFA-1 and TRAIL was measured in the livers of CHB patients and transfected cells.In general, high HBV replication in CHB patients and cell lines upregulated the mRNA of all NK cell ligands and particularly the inhibitory NK cell ligand, LLT1. The exception was the NKG2D ligand, MICA, that was significantly decreased in patients with high serum viremia and intrahepatic HBV RNA levels.HBV replication has differential effects on NK cell ligands suggesting a potential escape mechanisms through up-regulation of LLT1 and down-regulation of MICA. A general trend towards upregulating NK cell ligands can be counteracted by decreasing MICA and hence weakening NK surveillance." @default.
• W2344144712 created "2016-06-24" @default.
• W2344144712 creator A5002167750 @default.
• W2344144712 creator A5020193591 @default.
• W2344144712 creator A5063981177 @default.
• W2344144712 creator A5064787053 @default.
• W2344144712 creator A5080092427 @default.
• W2344144712 creator A5089010847 @default.
• W2344144712 date "2016-01-01" @default.
• W2344144712 modified "2023-09-25" @default.
• W2344144712 title "Hepatitis B viral replication influences the expression of natural killer cell ligands" @default.
• W2344144712 cites W1642437933 @default.
• W2344144712 cites W1669828090 @default.
• W2344144712 cites W1904297401 @default.
• W2344144712 cites W1912156696 @default.
• W2344144712 cites W1940739348 @default.
• W2344144712 cites W1966476186 @default.
• W2344144712 cites W1971673379 @default.
• W2344144712 cites W1985322739 @default.
• W2344144712 cites W1994936808 @default.
• W2344144712 cites W1999468210 @default.
• W2344144712 cites W2018479084 @default.
• W2344144712 cites W2028876452 @default.
• W2344144712 cites W2031693649 @default.
• W2344144712 cites W2045117050 @default.
• W2344144712 cites W2050571266 @default.
• W2344144712 cites W2060387930 @default.
• W2344144712 cites W2062560167 @default.
• W2344144712 cites W2071121923 @default.
• W2344144712 cites W2072690444 @default.
• W2344144712 cites W2077485054 @default.
• W2344144712 cites W2085737902 @default.
• W2344144712 cites W2092796827 @default.
• W2344144712 cites W2093938236 @default.
• W2344144712 cites W2095209396 @default.
• W2344144712 cites W2103972237 @default.
• W2344144712 cites W2104389844 @default.
• W2344144712 cites W2105866879 @default.
• W2344144712 cites W2112998733 @default.
• W2344144712 cites W2117407070 @default.
• W2344144712 cites W2119954580 @default.
• W2344144712 cites W2129628211 @default.
• W2344144712 cites W2130854591 @default.
• W2344144712 cites W2139858623 @default.
• W2344144712 cites W2141248446 @default.
• W2344144712 cites W2149232375 @default.
• W2344144712 cites W2156552801 @default.
• W2344144712 cites W2159044245 @default.
• W2344144712 cites W2162665513 @default.
• W2344144712 cites W2171229191 @default.
• W2344144712 doi "https://doi.org/10.20524/aog.2016.0036" @default.
• W2344144712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4923822" @default.
• W2344144712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27366037" @default.
• W2344144712 hasPublicationYear "2016" @default.
• W2344144712 type Work @default.
• W2344144712 sameAs 2344144712 @default.
• W2344144712 citedByCount "6" @default.
• W2344144712 countsByYear W23441447122017 @default.
• W2344144712 countsByYear W23441447122018 @default.
• W2344144712 countsByYear W23441447122022 @default.
• W2344144712 crossrefType "journal-article" @default.
• W2344144712 hasAuthorship W2344144712A5002167750 @default.
• W2344144712 hasAuthorship W2344144712A5020193591 @default.
• W2344144712 hasAuthorship W2344144712A5063981177 @default.
• W2344144712 hasAuthorship W2344144712A5064787053 @default.
• W2344144712 hasAuthorship W2344144712A5080092427 @default.
• W2344144712 hasAuthorship W2344144712A5089010847 @default.
• W2344144712 hasBestOaLocation W23441447121 @default.
• W2344144712 hasConcept C140704245 @default.
• W2344144712 hasConcept C154317977 @default.
• W2344144712 hasConcept C159047783 @default.
• W2344144712 hasConcept C194575299 @default.
• W2344144712 hasConcept C202751555 @default.
• W2344144712 hasConcept C203014093 @default.
• W2344144712 hasConcept C2522874641 @default.
• W2344144712 hasConcept C2775940106 @default.
• W2344144712 hasConcept C2776185481 @default.
• W2344144712 hasConcept C2777410769 @default.
• W2344144712 hasConcept C2778102761 @default.
• W2344144712 hasConcept C2778867473 @default.
• W2344144712 hasConcept C2780593183 @default.
• W2344144712 hasConcept C55493867 @default.
• W2344144712 hasConcept C73616013 @default.
• W2344144712 hasConcept C86803240 @default.
• W2344144712 hasConceptScore W2344144712C140704245 @default.
• W2344144712 hasConceptScore W2344144712C154317977 @default.
• W2344144712 hasConceptScore W2344144712C159047783 @default.
• W2344144712 hasConceptScore W2344144712C194575299 @default.
• W2344144712 hasConceptScore W2344144712C202751555 @default.
• W2344144712 hasConceptScore W2344144712C203014093 @default.
• W2344144712 hasConceptScore W2344144712C2522874641 @default.
• W2344144712 hasConceptScore W2344144712C2775940106 @default.
• W2344144712 hasConceptScore W2344144712C2776185481 @default.
• W2344144712 hasConceptScore W2344144712C2777410769 @default.
• W2344144712 hasConceptScore W2344144712C2778102761 @default.
• W2344144712 hasConceptScore W2344144712C2778867473 @default.
• W2344144712 hasConceptScore W2344144712C2780593183 @default.
• W2344144712 hasConceptScore W2344144712C55493867 @default.
• W2344144712 hasConceptScore W2344144712C73616013 @default.
• W2344144712 hasConceptScore W2344144712C86803240 @default.

• next