FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344156731> ?p ?o ?g. }

• W2344156731 endingPage "1237" @default.
• W2344156731 startingPage "1228" @default.
• W2344156731 abstract "ABO-incompatible (ABOi) organ transplantation is performed owing to unremitting donor shortages. Defining mechanisms of antibody-mediated rejection, accommodation, and tolerance of ABOi grafts is limited by lack of a suitable animal model. We report generation and characterization of a murine model to enable study of immunobiology in the setting of ABOi transplantation.Transgenesis of a construct containing human A1- and H-transferases under control of the ICAM-2 promoter was performed in C57BL/6 (B6) mice. A-transgenic (A-Tg) mice were assessed for A-antigen expression by histology and flow cytometry. B6 wild-type (WT) mice were sensitized with blood group A-human erythrocytes; others received passive anti-A monoclonal antibody and complement after heart transplant. Serum anti-A antibodies were assessed by hemagglutination. A-into-O transplantation (major histocompatibility complex syngeneic) was modeled by transplanting hearts from A-Tg mice into sensitized or nonsensitized WT mice. Antibody-mediated rejection was assessed by morphology/immunohistochemistry.A-Tg mice expressed A-antigen on vascular endothelium and other cells including erythrocytes. Antibody-mediated rejection was evident in 15/17 A-Tg grafts in sensitized WT recipients (median titer, 1:512), with 2 showing hyperacute rejection and rapid cessation of graft pulsation. Hyperacute rejection was observed in 8/8 A-Tg grafts after passive transfer of anti-A antibody and complement into nonsensitized recipients. Antibody-mediated rejection was not observed in A-Tg grafts transplanted into nonsensitized mice.A-Tg heart grafts transplanted into WT mice with abundant anti-A antibody manifests characteristic features of antibody-mediated rejection. These findings demonstrate an effective murine model to facilitate study of immunologic features of ABOi transplantation and to improve potential diagnostic and therapeutic strategies." @default.
• W2344156731 created "2016-06-24" @default.
• W2344156731 creator A5002801107 @default.
• W2344156731 creator A5005246771 @default.
• W2344156731 creator A5013709255 @default.
• W2344156731 creator A5023168693 @default.
• W2344156731 creator A5023171794 @default.
• W2344156731 creator A5036854871 @default.
• W2344156731 creator A5038480610 @default.
• W2344156731 creator A5039238202 @default.
• W2344156731 creator A5062115619 @default.
• W2344156731 creator A5065498227 @default.
• W2344156731 creator A5066995444 @default.
• W2344156731 creator A5067910050 @default.
• W2344156731 creator A5080300776 @default.
• W2344156731 creator A5081324343 @default.
• W2344156731 date "2016-06-01" @default.
• W2344156731 modified "2023-10-07" @default.
• W2344156731 title "Antibody-Mediated Rejection in a Blood Group A-Transgenic Mouse Model of ABO-Incompatible Heart Transplantation" @default.
• W2344156731 cites W1513657172 @default.
• W2344156731 cites W1580674042 @default.
• W2344156731 cites W1587393952 @default.
• W2344156731 cites W1963877462 @default.
• W2344156731 cites W1987549071 @default.
• W2344156731 cites W1998499070 @default.
• W2344156731 cites W1999610523 @default.
• W2344156731 cites W2007203700 @default.
• W2344156731 cites W2008335867 @default.
• W2344156731 cites W2009974217 @default.
• W2344156731 cites W2011991772 @default.
• W2344156731 cites W2020798663 @default.
• W2344156731 cites W2024501042 @default.
• W2344156731 cites W2029670167 @default.
• W2344156731 cites W2034427248 @default.
• W2344156731 cites W2037490243 @default.
• W2344156731 cites W2037817164 @default.
• W2344156731 cites W2038171012 @default.
• W2344156731 cites W2043371905 @default.
• W2344156731 cites W2045893344 @default.
• W2344156731 cites W2050846843 @default.
• W2344156731 cites W2056592635 @default.
• W2344156731 cites W2074162983 @default.
• W2344156731 cites W2075184601 @default.
• W2344156731 cites W2077516845 @default.
• W2344156731 cites W2086231877 @default.
• W2344156731 cites W2087603914 @default.
• W2344156731 cites W2090443192 @default.
• W2344156731 cites W2098773501 @default.
• W2344156731 cites W2101716510 @default.
• W2344156731 cites W2107224971 @default.
• W2344156731 cites W2108013658 @default.
• W2344156731 cites W2128302065 @default.
• W2344156731 cites W2150037328 @default.
• W2344156731 cites W2162373569 @default.
• W2344156731 doi "https://doi.org/10.1097/tp.0000000000001172" @default.
• W2344156731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27120451" @default.
• W2344156731 hasPublicationYear "2016" @default.
• W2344156731 type Work @default.
• W2344156731 sameAs 2344156731 @default.
• W2344156731 citedByCount "6" @default.
• W2344156731 countsByYear W23441567312019 @default.
• W2344156731 countsByYear W23441567312022 @default.
• W2344156731 countsByYear W23441567312023 @default.
• W2344156731 crossrefType "journal-article" @default.
• W2344156731 hasAuthorship W2344156731A5002801107 @default.
• W2344156731 hasAuthorship W2344156731A5005246771 @default.
• W2344156731 hasAuthorship W2344156731A5013709255 @default.
• W2344156731 hasAuthorship W2344156731A5023168693 @default.
• W2344156731 hasAuthorship W2344156731A5023171794 @default.
• W2344156731 hasAuthorship W2344156731A5036854871 @default.
• W2344156731 hasAuthorship W2344156731A5038480610 @default.
• W2344156731 hasAuthorship W2344156731A5039238202 @default.
• W2344156731 hasAuthorship W2344156731A5062115619 @default.
• W2344156731 hasAuthorship W2344156731A5065498227 @default.
• W2344156731 hasAuthorship W2344156731A5066995444 @default.
• W2344156731 hasAuthorship W2344156731A5067910050 @default.
• W2344156731 hasAuthorship W2344156731A5080300776 @default.
• W2344156731 hasAuthorship W2344156731A5081324343 @default.
• W2344156731 hasConcept C111684460 @default.
• W2344156731 hasConcept C126322002 @default.
• W2344156731 hasConcept C147483822 @default.
• W2344156731 hasConcept C159654299 @default.
• W2344156731 hasConcept C16685009 @default.
• W2344156731 hasConcept C176080213 @default.
• W2344156731 hasConcept C203014093 @default.
• W2344156731 hasConcept C22889606 @default.
• W2344156731 hasConcept C2778442404 @default.
• W2344156731 hasConcept C2778849806 @default.
• W2344156731 hasConcept C2911091166 @default.
• W2344156731 hasConcept C32611913 @default.
• W2344156731 hasConcept C542903549 @default.
• W2344156731 hasConcept C71924100 @default.
• W2344156731 hasConceptScore W2344156731C111684460 @default.
• W2344156731 hasConceptScore W2344156731C126322002 @default.
• W2344156731 hasConceptScore W2344156731C147483822 @default.
• W2344156731 hasConceptScore W2344156731C159654299 @default.
• W2344156731 hasConceptScore W2344156731C16685009 @default.
• W2344156731 hasConceptScore W2344156731C176080213 @default.

• next