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- W2344157029 abstract "Recent investigations in our laboratories have highlighted that the inhibition of the serine/threonine protein phosphatases 1 and 2A (PP1 and PP2A) is an excellent target for the development of novel anti-cancer agents. Using a combination of the known crystal structure of PP1 and the modelled structure of PP2A, we have rationally designed a new class of protein phosphatase inhibitors, cantharimides, which exhibit broad-spectrum anti-cancer activity. Synthetic modifications of the simplest known PP1 and PP2A inhibitor, norcantharidin, has led to the development of potent PP1 and PP2A inhibitors." @default.
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- W2344157029 date "2001-12-01" @default.
- W2344157029 modified "2023-09-23" @default.
- W2344157029 title "The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?" @default.
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