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- W2344170410 abstract "SUMMARY 1. Proteins are the workhorses of biological systems and, thus,it is not surprising that the field of proteomics has flourished inrecent years. The present review briefly surveys the general pro-teomic approaches taken to identify drug targets and to evaluatedrug efficacy and toxicity in the preclinical and clinical settings.These generally fall into three basic categories: a profilingapproach, a functional approach and a structural approach.2. The current ‘tools’ used and applied to the drug-discoveryprocess will be highlighted. These include the two-dimensionalgel electrophoresis, liquid chromatography, mass spectrometry,isotope-coded affinity tag and protein biochips.3. Clearly, proteomics has begun to set a foothold in everystage of the drug-discovery process. Future developments in thisarea will likely make a significant impact in our quest for better,safer and cost-effective drugs.Key words: chromatographic techniques, drug-discoveryprocess, mass spectrometry, protein chips, proteomics techno-logies, two-dimensional gel electrophoresis." @default.
- W2344170410 created "2016-06-24" @default.
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- W2344170410 date "2006-01-01" @default.
- W2344170410 modified "2023-09-27" @default.
- W2344170410 title "Frontiers in Research Review: Cutting-Edge Molecular Approaches to Therapeutics PROTEOMICS TECHNOLOGY AND THERAPEUTICS" @default.
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