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- W2344172647 endingPage "98" @default.
- W2344172647 startingPage "84" @default.
- W2344172647 abstract "MALDI-TOF MS technique is commonly used in system biology and clinical studies to search for new potential markers associated with pathological conditions. Despite numerous concerns regarding a sample preparation or processing of complex data, this strategy is still recognized as a popular tool and its awareness has risen in the proteomic community over the last decade. In this review, we present comprehensive application of MALDI mass spectrometry with special focus on profiling research. We also discuss major advantages and disadvantages of universal sample preparation methods such as micro-SPE columns, immunodepletion or magnetic beads, and we show the potential of nanostructured materials in capturing low molecular weight subproteomes. Furthermore, as the general protocol considerably affects spectra quality and interpretation, an alternative solution for improved ion detection, including hydrophobic constituents, data processing and statistical analysis is being considered in up-to-date profiling pattern. In conclusion, many reports involving MALDI-TOF MS indicated highly abundant proteins as valuable indicators, and at the same time showed the inaccuracy of available methods in the detection of low abundant proteome that is the most interesting from the clinical perspective. Therefore, the analytical aspects of sample preparation methods should be standardized to provide a reproducible, low sample handling and credible procedure." @default.
- W2344172647 created "2016-06-24" @default.
- W2344172647 creator A5000016260 @default.
- W2344172647 creator A5066340597 @default.
- W2344172647 creator A5071526508 @default.
- W2344172647 date "2016-07-01" @default.
- W2344172647 modified "2023-09-25" @default.
- W2344172647 title "Challenges in biomarker discovery with MALDI-TOF MS" @default.
- W2344172647 cites W1010312058 @default.
- W2344172647 cites W1016107859 @default.
- W2344172647 cites W1180477438 @default.
- W2344172647 cites W1482895581 @default.
- W2344172647 cites W1492136442 @default.
- W2344172647 cites W1539428042 @default.
- W2344172647 cites W1550213267 @default.
- W2344172647 cites W1597678601 @default.
- W2344172647 cites W1696400910 @default.
- W2344172647 cites W1787222175 @default.
- W2344172647 cites W1902650065 @default.
- W2344172647 cites W1939474206 @default.
- W2344172647 cites W1964714406 @default.
- W2344172647 cites W1965461426 @default.
- W2344172647 cites W1965528165 @default.
- W2344172647 cites W1965656780 @default.
- W2344172647 cites W1968449024 @default.
- W2344172647 cites W1969825815 @default.
- W2344172647 cites W1971152739 @default.
- W2344172647 cites W1971953276 @default.
- W2344172647 cites W1971987855 @default.
- W2344172647 cites W1976327004 @default.
- W2344172647 cites W1979092094 @default.
- W2344172647 cites W1981043819 @default.
- W2344172647 cites W1984709499 @default.
- W2344172647 cites W1985928045 @default.
- W2344172647 cites W1987769062 @default.
- W2344172647 cites W1987810103 @default.
- W2344172647 cites W1988049490 @default.
- W2344172647 cites W1989316455 @default.
- W2344172647 cites W1989447948 @default.
- W2344172647 cites W1990155580 @default.
- W2344172647 cites W1990389609 @default.
- W2344172647 cites W1992178856 @default.
- W2344172647 cites W1994710495 @default.
- W2344172647 cites W1995582835 @default.
- W2344172647 cites W1996409236 @default.
- W2344172647 cites W1996608824 @default.
- W2344172647 cites W1999728712 @default.
- W2344172647 cites W2000403772 @default.
- W2344172647 cites W2003067503 @default.
- W2344172647 cites W2007365177 @default.
- W2344172647 cites W2009416931 @default.
- W2344172647 cites W2019434020 @default.
- W2344172647 cites W2019539493 @default.
- W2344172647 cites W2021521601 @default.
- W2344172647 cites W2021828126 @default.
- W2344172647 cites W2022381933 @default.
- W2344172647 cites W2023370513 @default.
- W2344172647 cites W2023379093 @default.
- W2344172647 cites W2027424999 @default.
- W2344172647 cites W2028509886 @default.
- W2344172647 cites W2030502772 @default.
- W2344172647 cites W2032889185 @default.
- W2344172647 cites W2034276393 @default.
- W2344172647 cites W2034990238 @default.
- W2344172647 cites W2036717403 @default.
- W2344172647 cites W2037268730 @default.
- W2344172647 cites W2037800125 @default.
- W2344172647 cites W2038224125 @default.
- W2344172647 cites W2039115800 @default.
- W2344172647 cites W2039621259 @default.
- W2344172647 cites W2039703989 @default.
- W2344172647 cites W2042629343 @default.
- W2344172647 cites W2042729651 @default.
- W2344172647 cites W2043508059 @default.
- W2344172647 cites W2047357083 @default.
- W2344172647 cites W2050083056 @default.
- W2344172647 cites W2051301080 @default.
- W2344172647 cites W2051591752 @default.
- W2344172647 cites W2052305317 @default.
- W2344172647 cites W2052779852 @default.
- W2344172647 cites W2053032913 @default.
- W2344172647 cites W2055319410 @default.
- W2344172647 cites W2055545476 @default.
- W2344172647 cites W2056318045 @default.
- W2344172647 cites W2057356121 @default.
- W2344172647 cites W2058135122 @default.
- W2344172647 cites W2058653140 @default.
- W2344172647 cites W2059179399 @default.
- W2344172647 cites W2060048225 @default.
- W2344172647 cites W2060176486 @default.
- W2344172647 cites W2060978106 @default.
- W2344172647 cites W2061637917 @default.
- W2344172647 cites W2064347820 @default.
- W2344172647 cites W2069889056 @default.
- W2344172647 cites W2070515870 @default.
- W2344172647 cites W2073190861 @default.
- W2344172647 cites W2073414836 @default.
- W2344172647 cites W2073649272 @default.