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- W2344188147 abstract "ABSTRACT Aim: Thymic carcinomas are considered to be more aggressive than thymomas and carry a worse prognosis. Although a multimodality treatment is made in many cases as for thymic carcinomas, optimal therapeutic strategy still remains controversial. In the present study, we attempted to clarify the prognostic factors based on the survival to establish suitable treatment strategy. Methods: We performed a single-institution retrospective cohort study. Between June 1987 and October 2012, 70 patients were eventually given a diagnosis of thymic carcinoma. Data included patient demographics, stage, first treatment (e.g. chemotherapy (CT), chemoradiotherapy (CRT), and surgery (S)), pathologic findings, and outcomes. Results: The overall 2- and 5-year survival rate was 61.9% and 36.4%, respectively; mean and median observation time was 30M and 24M, respectively. Two-year survival rates in patients treated with CT, CRT, and S group were 38.7, 52.4, and 80.5%, and 5-year survival rates in patients treated with CT, CRT, and S group were 17.4, 21.0, and 55% for all patients. S group showed significantly better prognosis than the others in overall stage (p=0.0006). Patients undergoing S, however, had similar survival compared with undergoing CT or CRT alone in stage IV a,b subset; CT vs. CRT (p=0.6598), CT vs. S (p=0.1159), CRTvs.S (p=0.3030). Univariate analysis among all patients revealed two significant prognostic factors (P Conclusions: Our analyses indicated that stage by the Masaoka system and type of first treatment would have the prognostic impact. If complete excision is possible at earlier than Masaoka stage III, it may be cured completely. The role of debulking surgery at stage IV a,b was negative. Patient selection, accurate staging, and choice of anticancer drug with a high response rate may be critical to optimizing outcomes. Disclosure: All authors have declared no conflicts of interest." @default.
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- W2344188147 date "2014-09-01" @default.
- W2344188147 modified "2023-09-29" @default.
- W2344188147 title "A Multivariate Analysis of Factors Predicting Survival in 70 Patients with Thymic Carcinoma: Implications for Treatment Strategy" @default.
- W2344188147 doi "https://doi.org/10.1093/annonc/mdu357.8" @default.
- W2344188147 hasPublicationYear "2014" @default.
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