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• W2344201058 abstract "ABSTRACTIntroduction: Fluoropyrimidines have been a critical component to chemotherapy regimens to treat locally advanced and metastatic colorectal cancer since the 1950s. Clinicians should be aware of the methods that exist to personalize fluoropyrimidine administration to increase efficacy and reduce toxicity.Areas covered: The development of different administration methods (e.g. bolus versus continuous infusion, oral formulations) have advanced the clinical utility of fluoropyrimidines to treat colorectal cancer. Given the high inter-patient variation in fluoropyrimidine drug exposure and susceptibility to pharmacogenetic variation, pharmacokinetic- and pharmacogenetic-guided dosing may also prove fruitful in the quest to normalize drug exposure, reduce toxicity and enhance clinical efficacy. PubMed was used to search for relevant articles relating to 5-fluorouracil administration, fluoropyrimidines (S-1, tegafur, capecitabine, TAS-102), 5-fluorouracil pharmacokinetics and pharmacogenetics, and person..." @default.
• W2344201058 created "2016-06-24" @default.
• W2344201058 creator A5017645198 @default.
• W2344201058 creator A5060396450 @default.
• W2344201058 date "2016-04-27" @default.
• W2344201058 modified "2023-09-26" @default.
• W2344201058 title "Personalizing fluoropyrimidine administration in colorectal cancer patients" @default.
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• W2344201058 doi "https://doi.org/10.1080/23808993.2016.1176860" @default.
• W2344201058 hasPublicationYear "2016" @default.
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