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• W2344233709 endingPage "488" @default.
• W2344233709 startingPage "463" @default.
• W2344233709 abstract "Oxidative stress has been increasingly recognized as a major contributing factor in a variety of human diseases, from inflammation to cancer. Although certain parts of signaling pathways are still under investigation, detailed molecular mechanisms for the induction of diseases have been elucidated, especially the link between excessive oxygen reactive species (ROS) damage and tumorigenesis. Emerging evidence suggests anti-oxidant therapy can play a key role in treating those diseases. Among potential drug resources, plant polysaccharides are natural anti-oxidant constituents important for human health because of their long history in ethnopharmacology, wide availability and few side effects upon consumption. Plant polysaccharides have been shown to possess anti-oxidant, anti-inflammation, cell viability promotion, immune-regulation and antitumor functions in a number of disease models, both in laboratory studies and in the clinic. In this paper, we reviewed the research progress of signaling pathways involved in the initiation and progression of oxidative stress- and cancer-related diseases in humans. The natural sources, structural properties and biological actions of several common plant polysaccharides, including Lycium barbarum, Ginseng, Zizyphus Jujuba, Astragalus lentiginosus, and Ginkgo biloba are discussed in detail, with emphasis on their signaling pathways. All of the mentioned common plant polysaccharides have great potential to treat oxidative stress and cancinogenic disorders in cell models, animal disease models and clinical cases. ROS-centered pathways (e.g. mitochondrial autophagy, MAPK and JNK) and transcription factor-related pathways (e.g. NF-[Formula: see text]B and HIF) are frequently utilized by these polysaccharides with or without the further involvement of inflammatory and death receptor pathways. Some of the polysaccharides may also influence tumorigenic pathways, such as Wnt and p53 to play their anti-tumor roles. In addition, current problems and future directions for the application of those plant polysaccharides are also listed and discussed." @default.
• W2344233709 created "2016-06-24" @default.
• W2344233709 creator A5005434770 @default.
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• W2344233709 creator A5030627810 @default.
• W2344233709 creator A5057891283 @default.
• W2344233709 creator A5091107099 @default.
• W2344233709 date "2016-01-01" @default.
• W2344233709 modified "2023-10-16" @default.
• W2344233709 title "The Anti-Oxidant and Antitumor Properties of Plant Polysaccharides" @default.
• W2344233709 cites W1420152522 @default.
• W2344233709 cites W1547863599 @default.
• W2344233709 cites W1555383704 @default.
• W2344233709 cites W1588901901 @default.
• W2344233709 cites W1723007531 @default.
• W2344233709 cites W1736962860 @default.
• W2344233709 cites W1758290145 @default.
• W2344233709 cites W1917920132 @default.
• W2344233709 cites W1963796196 @default.
• W2344233709 cites W1965009601 @default.
• W2344233709 cites W1965623465 @default.
• W2344233709 cites W1966833346 @default.
• W2344233709 cites W1968044382 @default.
• W2344233709 cites W1968202620 @default.
• W2344233709 cites W1972673389 @default.
• W2344233709 cites W1973256703 @default.
• W2344233709 cites W1976643329 @default.
• W2344233709 cites W1976950210 @default.
• W2344233709 cites W1978920731 @default.
• W2344233709 cites W1981711832 @default.
• W2344233709 cites W1982049788 @default.
• W2344233709 cites W1982330633 @default.
• W2344233709 cites W1983072310 @default.
• W2344233709 cites W1986015269 @default.
• W2344233709 cites W1986564239 @default.
• W2344233709 cites W1987107897 @default.
• W2344233709 cites W1988131776 @default.
• W2344233709 cites W1988237468 @default.
• W2344233709 cites W1989468718 @default.
• W2344233709 cites W1991497480 @default.
• W2344233709 cites W1992422835 @default.
• W2344233709 cites W1994101167 @default.
• W2344233709 cites W1996895493 @default.
• W2344233709 cites W1996978624 @default.
• W2344233709 cites W1997700298 @default.
• W2344233709 cites W1998231995 @default.
• W2344233709 cites W1998383513 @default.
• W2344233709 cites W2002930228 @default.
• W2344233709 cites W2003196442 @default.
• W2344233709 cites W2003827942 @default.
• W2344233709 cites W2004025099 @default.
• W2344233709 cites W2004916218 @default.
• W2344233709 cites W2006021799 @default.
• W2344233709 cites W2006883110 @default.
• W2344233709 cites W2007800802 @default.
• W2344233709 cites W2008443022 @default.
• W2344233709 cites W2009082960 @default.
• W2344233709 cites W2010077871 @default.
• W2344233709 cites W2010723875 @default.
• W2344233709 cites W2010842946 @default.
• W2344233709 cites W2013692599 @default.
• W2344233709 cites W2017228791 @default.
• W2344233709 cites W2017663240 @default.
• W2344233709 cites W2017674628 @default.
• W2344233709 cites W2019303838 @default.
• W2344233709 cites W2019471421 @default.
• W2344233709 cites W2021117493 @default.
• W2344233709 cites W2021331145 @default.
• W2344233709 cites W2023891996 @default.
• W2344233709 cites W2025005378 @default.
• W2344233709 cites W2025962043 @default.
• W2344233709 cites W2026209195 @default.
• W2344233709 cites W2026897178 @default.
• W2344233709 cites W2027633674 @default.
• W2344233709 cites W2028377151 @default.
• W2344233709 cites W2028873536 @default.
• W2344233709 cites W2031784846 @default.
• W2344233709 cites W2033910705 @default.
• W2344233709 cites W2034141861 @default.
• W2344233709 cites W2037003766 @default.
• W2344233709 cites W2038041800 @default.
• W2344233709 cites W2038058558 @default.
• W2344233709 cites W2038225067 @default.
• W2344233709 cites W2038396805 @default.
• W2344233709 cites W2040732103 @default.
• W2344233709 cites W2041946874 @default.
• W2344233709 cites W2042388228 @default.
• W2344233709 cites W2043221891 @default.
• W2344233709 cites W2045253061 @default.
• W2344233709 cites W2045907249 @default.
• W2344233709 cites W2048553024 @default.
• W2344233709 cites W2048919253 @default.
• W2344233709 cites W2050353596 @default.
• W2344233709 cites W2052302181 @default.
• W2344233709 cites W2052846830 @default.
• W2344233709 cites W2052992630 @default.
• W2344233709 cites W2055860494 @default.
• W2344233709 cites W2056177287 @default.

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