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• W2344235963 abstract "To evaluate if time to treatment (TTT) has any effects on outcomes for patients with localized prostate cancer treated with definitive external beam radiation therapy (EBRT). We included all patients with localized prostate cancer treated with definitive EBRT between 1989 and 2013. Patients with prior treatment for prostate cancer, incomplete information regarding biopsy date or cancer risk stratification, on active surveillance, with TTT >2 years, or follow up <1 year were excluded. For each National Comprehensive Cancer Network risk-stratification group, TTT (defined as the time between the initial positive prostate biopsy and start of RT) was analyzed in 4 intervals: <3, 3 to 6, 6 to 9 (not including 6), and >9 months (m). Use of neoadjuvant-adjuvant androgen deprivation therapy (ADT) was also recorded, to evaluate if ADT influences the effects of TTT on outcomes for patients with high-risk factors (RF, defined as any of the following: PSA >20 ng/mL, Gleason 8-10, T3-T4). A total of 4064 patients including 1549 low risk (LR), 1612 intermediate risk (IR), and 903 high risk (HR) were eligible. The median TTT was 3.3 m (range 0.6 to 23.5 m) for all the patients, and the median TTT was similar for each risk group (3.3-3.4 m). The median follow-up was 64 m (range 12 to 255.6 m). There were no significant differences in biochemical failure (BF), distant metastasis (DM), or overall survival (OS) for patients with TTT <3, 3 to 6, 6 to 9, or >9 m for each risk group. For the 2089 patients with TTT >3.3 m, median TTT was 4.4 m (range 3.3 to 23.5 m), including 837 LR, 802 IR, and 450 HR. There were no significant differences in the outcomes at 5 years when patients with TTT>3.3 m were compared to those with TTT ≤3.3 m for each risk group (table). For HR patients, 328 out 450 (72.9%) with TTT >3.3 m were on ADT versus 299 out of 453 (66%) with TTT ≤3.3 m. HR patients on ADT had more RF (1RF, 2RFs, 3 RFs: 68.7%, 27.4%, 3.9%, respectively) compared to those with RT alone (89.1%, 10.2%, 0.7%) with P≤.001. When only the HR patients without ADT were analyzed, there were still no significant differences in the outcomes between TTT >3.3 m and TTT ≤3.3 m. Time to treatment (<3, 3-6, 6-9, or 9-24 m) does not make significant difference in outcomes within each risk group for men with localized prostate cancer treated with RT. The majority of patients in the HR group were on ADT, and men with more RFs were more likely to receive ADT. However, among the HR group there were no observed detriments in outcomes with TTT >3.3 m, regardless of ADT use.Poster Viewing Abstracts 2595; TableComparison of BCF, DM, and OS for patients in each risk group with TTT ≤3.3 m versus >3.3 m.Risk groupBCF (%) at 5 yearsDM (%) at 5 yearsOS (%) at 5 yearsTTT≤3.3 m>3.3 mp≤3.3 m>3.3 mp≤3.3 m>3.3 mPlow3.23.70.640.40.80.3695.294.7.32intermediate11.110.60.743.53.10.2288.490.3.51highall25.122.30.1910.78.00.0686.386.9.97ADT18.318.70.429.78.30.2186.287.2.91N0 ADT36.532.20.9012.56.90.3286.386.1.85 Open table in a new tab" @default.
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• W2344235963 date "2015-11-01" @default.
• W2344235963 modified "2023-09-26" @default.
• W2344235963 title "Effects of Time to Treatment on Biochemical and Clinical Outcomes for Patients With Prostate Cancer Treated With Definitive Radiation" @default.
• W2344235963 doi "https://doi.org/10.1016/j.ijrobp.2015.07.1149" @default.
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