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- W2344249311 abstract "Objective To study the radiosensitive effect of Aidi injection on human lung adenocarcinoma cell line A549 and the relative mechanism.Methods(1)The inhibitory effect of the medicine on A549 cells was analyzed by MTT assay.IC50 concentration was calculated.(2)The radiosensitization was observed with the method of clone forming assay.(3)Flow cytometry was used to analyze the effect of the medicine on cell cycle and apoptosis.Results The growth of A549 cells was inhibited after the cells were exposed to the medicine for 48 hours.The inhibitory rates increased with the increasing concentrations of the medicine.IC50 was 16.04 mg/mL.Contrast to the radiation alone group,the survival rates of the cells in medicine plus radiation groups decreased.The medicine enhanced the radiosensitivity of the cells.This effect increased as cells exposed to the medicine for longer time.In the radiation alone group and the two groups exposed to the medicine for 24 hours and 48 hours before radiation,D0 values were 2.13 Gy,2.04 Gy,1.64 Gy and Dq values were 2.88 Gy,1.68 Gy,1.51 Gy,respectively.In the last two groups,SERD0 values were 1.04,1.3 and SERDq values were 1.71,1.91,respectively.The method of flow cytometry showed that the medicine induced G2/M phase block and increased the apoptosis rates.With the increasing exposed time,the effects were more remarkable.Conclusions Aidi injection could inhibit the growth and enhance the radiosensitivity of A549 cells.The relative radiosensitization mechanism may include inhibition of sublethal injury repair,G2/M phase block and induced apoptosis." @default.
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- W2344249311 date "2010-01-01" @default.
- W2344249311 modified "2023-09-24" @default.
- W2344249311 title "Radiosensitization of Aidi injection on human lung adenocarcinoma cell line A549" @default.
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