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- W2344319761 abstract "Significance Erythropoietin is used to treat anemia but has prothrombotic side effects that limit its use. We have demonstrated in vivo the ability to target erythropoietin to red blood cell precursors and away from platelet precursors, thereby potentially avoiding off-target effects. We have systematically determined the protein design features required for in vivo success of the engineered protein. Our results reveal how rational engineering of protein drugs can be used to reduce side effects, with broad implications for designers of therapeutic signaling systems." @default.
- W2344319761 created "2016-06-24" @default.
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- W2344319761 date "2016-04-25" @default.
- W2344319761 modified "2023-10-17" @default.
- W2344319761 title "Targeted erythropoietin selectively stimulates red blood cell expansion in vivo" @default.
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- W2344319761 doi "https://doi.org/10.1073/pnas.1525388113" @default.
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