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- W2344327404 abstract "Ascorbic acid (A) has been demonstrated to exhibit anti-cancer activity in association with chemotherapeutic agents. Potassium (K) is a regulator of cellular proliferation. In the present study, the biological effects of A and K bicarbonate, alone or in combination (A+K), on breast cancer cell lines were evaluated. The survival of cancer cells was determined by sulforhodamine B cell proliferation assay, while analysis of the cell cycle distribution was conducted via fluorescence-activated cell sorting. In addition, the expression of signaling proteins was analyzed upon treatment. The results indicated that there was a heterogeneous response of the different cell lines to A and K, and the best effects were achieved by A+K and A treatment. The interaction between A+K indicated an additive or synergistic effect. In addition, A+K increased the percentage of cells in the sub‑G1 phase of the cell cycle, and was the most effective treatment in activating the degradation of poly(adenosine diphosphate-ribose) polymerase-1. In the breast cancer cell line MCF‑7, A+K induced the appearance of the 18 kDa isoform of B‑cell lymphoma‑2‑associated X protein (Bax), which is a more potent inducer of apoptosis than the full‑length Bax‑p21. The effects of A and K on the phosphorylation of extracellular signal‑regulated kinase (ERK)1 and ERK2 were heterogeneous. In addition, treatment with K, A and A+K inhibited the expression of nuclear factor‑κB. Overall, the results of the present study indicated that K potentiated the anti-tumoral effects of A in breast cancer cells in vitro." @default.
- W2344327404 created "2016-06-24" @default.
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- W2344327404 date "2016-04-27" @default.
- W2344327404 modified "2023-10-16" @default.
- W2344327404 title "Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines in vitro" @default.
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- W2344327404 doi "https://doi.org/10.3892/ol.2016.4506" @default.
- W2344327404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4888082" @default.
- W2344327404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27313770" @default.
- W2344327404 hasPublicationYear "2016" @default.
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