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• W2344332597 abstract "Background: Acute myocardial infarction is the leading cause of morbidity and mortality worldwide. Furthermore, research has shown that exercise, in addition to reducing cardiovascular risk factors, can also protect the heart against injury due to ischemia and reperfusion through a direct effect on the myocardium. However, the specific mechanism involved in exercise-induced cardiac preconditioning is still under debate. Objective: To perform a systematic review of the studies that have addressed the mechanisms by which aerobic exercise promotes direct cardioprotection against ischemia and reperfusion injury. Methods: A search was conducted using MEDLINE, Literatura Latino-Americana e do Caribe de Informacao em Ciencias da Saude, and Scientific Electronic Library Online databases. Data were extracted in a standardized manner by two independent researchers, who were responsible for assessing the methodological quality of the studies. Results: The search retrieved 78 studies; after evaluating the abstracts, 30 studies were excluded. The manuscripts of the remaining 48 studies were completely read and, of these, 20 were excluded. Finally, 28 studies were included in this systematic review. Conclusion: On the basis of the selected studies, the following are potentially involved in the cardioprotective response to exercise: increased heat shock protein production, nitric oxide pathway involvement, increased cardiac antioxidant capacity, improvement in ATP-dependent potassium channel function, and opioid system activation. Despite all the previous investigations, further research is still necessary to obtain more consistent conclusions." @default.
• W2344332597 created "2016-06-24" @default.
• W2344332597 creator A5026752181 @default.
• W2344332597 creator A5086129317 @default.
• W2344332597 date "2014-01-01" @default.
• W2344332597 modified "2023-09-26" @default.
• W2344332597 title "Mecanismos Envolvidos na Cardioproteção Induzida pelo Exercício Físico: Uma Revisão Sistemática Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review" @default.
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