FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344334611> ?p ?o ?g. }

• W2344334611 endingPage "djw100" @default.
• W2344334611 startingPage "djw100" @default.
• W2344334611 abstract "Background: HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only certain infections progress. HPV16 can be classified into four main evolutionary-derived variant lineages (A, B, C, D) that have been previously suggested to have varying disease risks. Methods: We used a high-throughput HPV16 whole-genome sequencing assay to investigate variant lineage risk among 3215 HPV16-infected women. Using sublineages A1/A2 as the reference, we assessed all variant lineage associations with infection outcome over three or more years of follow-up: 1107 control subjects (<CIN2), 906 CIN2, 1008 CIN3, 69 squamous cell carcinomas (SCC), 85 adenocarcinomas in situ (AIS), and 40 adenocarcinomas. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: A4 sublineage was associated with an increased risk of cancer, specifically adenocarcinoma (OR = 9.81, 95% CI = 2.02 to 47.69, P = 4.7x10 −03 ). Lineage B had a lower risk of CIN3 (OR = 0.51, 95% CI = 0. 28 to 0.91, P = .02) while lineage C showed increased risk (OR = 2.06, 95% CI = 1.09 to 3.89, P = .03). D2/D3 sublineages were strongly associated with an increased risk of CIN3 and cancer, particularly D2 (OR for cancer = 28.48, 95% CI = 9.27 to 87.55, P = 5.0x10 −09 ). D2 had the strongest increased risk of glandular lesions, AIS (OR = 29.22, 95% CI = 8.94 to 95.51, P = 2.3x10 −08 ), and adenocarcinomas (OR = 137.34, 95% CI = 37.21 to 506.88, P = 1.5x10 −13 ). Moreover, the risk of precancer and cancer for specific variant lineages varied by a women’s race/ethnicity; those women whose race/ethnicity matched that of the infecting HPV16 variant had an increased risk of CIN3 + ( P < .001). Conclusions: Specific HPV16 variant sublineages strongly influence risk of histologic types of precancer and cancer, and viral genetic variation may help explain its unique carcinogenic properties." @default.
• W2344334611 created "2016-06-24" @default.
• W2344334611 creator A5004348236 @default.
• W2344334611 creator A5004506157 @default.
• W2344334611 creator A5010098599 @default.
• W2344334611 creator A5021442543 @default.
• W2344334611 creator A5023785428 @default.
• W2344334611 creator A5032443275 @default.
• W2344334611 creator A5041828111 @default.
• W2344334611 creator A5042212667 @default.
• W2344334611 creator A5056991781 @default.
• W2344334611 creator A5059813707 @default.
• W2344334611 creator A5059951020 @default.
• W2344334611 creator A5060888364 @default.
• W2344334611 creator A5065617411 @default.
• W2344334611 creator A5066156238 @default.
• W2344334611 creator A5073008351 @default.
• W2344334611 creator A5077804071 @default.
• W2344334611 creator A5086799366 @default.
• W2344334611 creator A5087166167 @default.
• W2344334611 creator A5089867910 @default.
• W2344334611 date "2016-04-29" @default.
• W2344334611 modified "2023-10-12" @default.
• W2344334611 title "HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women" @default.
• W2344334611 cites W1488402216 @default.
• W2344334611 cites W1761353211 @default.
• W2344334611 cites W1972036595 @default.
• W2344334611 cites W1973393550 @default.
• W2344334611 cites W1977942351 @default.
• W2344334611 cites W1980072911 @default.
• W2344334611 cites W1984669473 @default.
• W2344334611 cites W1994758270 @default.
• W2344334611 cites W2004805218 @default.
• W2344334611 cites W2008193938 @default.
• W2344334611 cites W2009933647 @default.
• W2344334611 cites W2011676004 @default.
• W2344334611 cites W2013068290 @default.
• W2344334611 cites W2017928122 @default.
• W2344334611 cites W2020386919 @default.
• W2344334611 cites W2024151627 @default.
• W2344334611 cites W2026598187 @default.
• W2344334611 cites W2036641307 @default.
• W2344334611 cites W2039745983 @default.
• W2344334611 cites W2043431910 @default.
• W2344334611 cites W2064099545 @default.
• W2344334611 cites W2065150919 @default.
• W2344334611 cites W2072155047 @default.
• W2344334611 cites W2081008159 @default.
• W2344334611 cites W2085552258 @default.
• W2344334611 cites W2101758659 @default.
• W2344334611 cites W2101899141 @default.
• W2344334611 cites W2102536992 @default.
• W2344334611 cites W2108124592 @default.
• W2344334611 cites W2108506470 @default.
• W2344334611 cites W2128282825 @default.
• W2344334611 cites W2132386777 @default.
• W2344334611 cites W2134770844 @default.
• W2344334611 cites W2136304428 @default.
• W2344334611 cites W2137989706 @default.
• W2344334611 cites W2139736159 @default.
• W2344334611 cites W2143158562 @default.
• W2344334611 cites W2153866279 @default.
• W2344334611 cites W2159416556 @default.
• W2344334611 cites W2162954621 @default.
• W2344334611 cites W2166632132 @default.
• W2344334611 cites W2167639680 @default.
• W2344334611 cites W2168696662 @default.
• W2344334611 cites W2169918603 @default.
• W2344334611 cites W2170726298 @default.
• W2344334611 cites W2171917485 @default.
• W2344334611 cites W2192486276 @default.
• W2344334611 doi "https://doi.org/10.1093/jnci/djw100" @default.
• W2344334611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5939630" @default.
• W2344334611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27130930" @default.
• W2344334611 hasPublicationYear "2016" @default.
• W2344334611 type Work @default.
• W2344334611 sameAs 2344334611 @default.
• W2344334611 citedByCount "140" @default.
• W2344334611 countsByYear W23443346112016 @default.
• W2344334611 countsByYear W23443346112017 @default.
• W2344334611 countsByYear W23443346112018 @default.
• W2344334611 countsByYear W23443346112019 @default.
• W2344334611 countsByYear W23443346112020 @default.
• W2344334611 countsByYear W23443346112021 @default.
• W2344334611 countsByYear W23443346112022 @default.
• W2344334611 countsByYear W23443346112023 @default.
• W2344334611 crossrefType "journal-article" @default.
• W2344334611 hasAuthorship W2344334611A5004348236 @default.
• W2344334611 hasAuthorship W2344334611A5004506157 @default.
• W2344334611 hasAuthorship W2344334611A5010098599 @default.
• W2344334611 hasAuthorship W2344334611A5021442543 @default.
• W2344334611 hasAuthorship W2344334611A5023785428 @default.
• W2344334611 hasAuthorship W2344334611A5032443275 @default.
• W2344334611 hasAuthorship W2344334611A5041828111 @default.
• W2344334611 hasAuthorship W2344334611A5042212667 @default.
• W2344334611 hasAuthorship W2344334611A5056991781 @default.
• W2344334611 hasAuthorship W2344334611A5059813707 @default.
• W2344334611 hasAuthorship W2344334611A5059951020 @default.

• next