Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344376460> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2344376460 endingPage "37" @default.
- W2344376460 startingPage "929" @default.
- W2344376460 abstract "Previous findings, which have been confirmed in this study, indicate that nitric oxide (NO)-dependent and -independent (apamin-sensitive) mechanisms underlie the electrically induced non-adrenergic, noncholinergic (NANC) relaxation in the circular muscle of rabbit distal colon. Based on this evidence, we further investigated whether, and to what extent, these separate NANC components participate in the maintenance of circular muscle tone, reflex relaxations evoked by localized balloon distension or during peristalsis (descending inhibition) and in the accommodation of colonic wall in response to graded intraluminal fluid delivery. NG-nitro-L-arginine (L-NNA) (10-300 microM), apamin (100 nM) and tetrodotoxin (60 nM), enhanced the spontaneous low tone and phasic activity in circular muscle strips. In experiments on peristalsis, L-NNA (30 and 300 microM) shortened the latency of peristaltic wave initiation and increased the velocity of propulsion of an intraluminally distended balloon (range, 0.1-1 ml). The latter effect was mimicked by the NO scavenger oxyhemoglobin (30 microM). Velocity of propulsion was enhanced by apamin (100 nM) at low balloon distension (0.1 and 0.2 ml), whereas it was reduced at high distension volumes (1 ml), due to disruption of descending inhibition. A combination of L-NNA (300 microM) and apamin (100 nM) blocked peristalsis, due to persisting spasms of the circular muscle. L-NNA (300 microM) did not affect the amplitude of distension-evoked ascending reflex contraction and slightly inhibited the descending reflex relaxation. By contrast, the latter reflex was virtually abolished by apamin (100 nM).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2344376460 created "2016-06-24" @default.
- W2344376460 creator A5032011775 @default.
- W2344376460 creator A5050311941 @default.
- W2344376460 creator A5067892973 @default.
- W2344376460 creator A5070129664 @default.
- W2344376460 creator A5072943433 @default.
- W2344376460 creator A5085838083 @default.
- W2344376460 date "1994-09-01" @default.
- W2344376460 modified "2023-10-06" @default.
- W2344376460 title "Role of nitric oxide-dependent and -independent mechanisms in peristalsis and accommodation in the rabbit distal colon." @default.
- W2344376460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7932205" @default.
- W2344376460 hasPublicationYear "1994" @default.
- W2344376460 type Work @default.
- W2344376460 sameAs 2344376460 @default.
- W2344376460 citedByCount "10" @default.
- W2344376460 crossrefType "journal-article" @default.
- W2344376460 hasAuthorship W2344376460A5032011775 @default.
- W2344376460 hasAuthorship W2344376460A5050311941 @default.
- W2344376460 hasAuthorship W2344376460A5067892973 @default.
- W2344376460 hasAuthorship W2344376460A5070129664 @default.
- W2344376460 hasAuthorship W2344376460A5072943433 @default.
- W2344376460 hasAuthorship W2344376460A5085838083 @default.
- W2344376460 hasConcept C105702510 @default.
- W2344376460 hasConcept C126322002 @default.
- W2344376460 hasConcept C134018914 @default.
- W2344376460 hasConcept C185592680 @default.
- W2344376460 hasConcept C206813253 @default.
- W2344376460 hasConcept C2776625112 @default.
- W2344376460 hasConcept C2776919887 @default.
- W2344376460 hasConcept C2777032099 @default.
- W2344376460 hasConcept C42219234 @default.
- W2344376460 hasConcept C519581460 @default.
- W2344376460 hasConcept C71924100 @default.
- W2344376460 hasConcept C83743174 @default.
- W2344376460 hasConcept C83974742 @default.
- W2344376460 hasConceptScore W2344376460C105702510 @default.
- W2344376460 hasConceptScore W2344376460C126322002 @default.
- W2344376460 hasConceptScore W2344376460C134018914 @default.
- W2344376460 hasConceptScore W2344376460C185592680 @default.
- W2344376460 hasConceptScore W2344376460C206813253 @default.
- W2344376460 hasConceptScore W2344376460C2776625112 @default.
- W2344376460 hasConceptScore W2344376460C2776919887 @default.
- W2344376460 hasConceptScore W2344376460C2777032099 @default.
- W2344376460 hasConceptScore W2344376460C42219234 @default.
- W2344376460 hasConceptScore W2344376460C519581460 @default.
- W2344376460 hasConceptScore W2344376460C71924100 @default.
- W2344376460 hasConceptScore W2344376460C83743174 @default.
- W2344376460 hasConceptScore W2344376460C83974742 @default.
- W2344376460 hasIssue "3" @default.
- W2344376460 hasLocation W23443764601 @default.
- W2344376460 hasOpenAccess W2344376460 @default.
- W2344376460 hasPrimaryLocation W23443764601 @default.
- W2344376460 hasRelatedWork W1623258072 @default.
- W2344376460 hasRelatedWork W1972531775 @default.
- W2344376460 hasRelatedWork W1973001708 @default.
- W2344376460 hasRelatedWork W1982907661 @default.
- W2344376460 hasRelatedWork W2048750297 @default.
- W2344376460 hasRelatedWork W2163475302 @default.
- W2344376460 hasRelatedWork W2178829069 @default.
- W2344376460 hasRelatedWork W2274879254 @default.
- W2344376460 hasRelatedWork W2344376460 @default.
- W2344376460 hasRelatedWork W2981171950 @default.
- W2344376460 hasVolume "270" @default.
- W2344376460 isParatext "false" @default.
- W2344376460 isRetracted "false" @default.
- W2344376460 magId "2344376460" @default.
- W2344376460 workType "article" @default.