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- W2344480512 endingPage "121" @default.
- W2344480512 startingPage "121" @default.
- W2344480512 abstract "Acute respiratory distress syndrome (ARDS) is a syndrome with heterogeneous underlying pathological processes. It represents a common clinical problem in intensive care unit patients and it is characterized by high mortality. The mainstay of treatment for ARDS is lung protective ventilation with low tidal volumes and positive end-expiratory pressure sufficient for alveolar recruitment. Prone positioning is a supplementary strategy available in managing patients with ARDS. It was first described 40 years ago and it proves to be in alignment with two major ARDS pathophysiological lung models; the sponge lung - and the shape matching -model. Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics as it redistributes transpulmonary pressure, stress and strain throughout the lung and unloads the right ventricle. The factors that individually influence the time course of alveolar recruitment and the improvement in oxygenation during prone positioning have not been well characterized. Although patients' response to prone positioning is quite variable and hard to predict, large randomized trials and recent meta-analyses show that prone position in conjunction with a lung-protective strategy, when performed early and in sufficient duration, may improve survival in patients with ARDS. This pathophysiology-based review and recent clinical evidence strongly support the use of prone positioning in the early management of severe ARDS systematically and not as a rescue maneuver or a last-ditch effort." @default.
- W2344480512 created "2016-06-24" @default.
- W2344480512 creator A5005905582 @default.
- W2344480512 creator A5026627542 @default.
- W2344480512 creator A5060111369 @default.
- W2344480512 creator A5071578233 @default.
- W2344480512 date "2016-01-01" @default.
- W2344480512 modified "2023-10-04" @default.
- W2344480512 title "Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review" @default.
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