FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344494025> ?p ?o ?g. }

• W2344494025 endingPage "15" @default.
• W2344494025 startingPage "6" @default.
• W2344494025 abstract "Successful stem cell therapy after acute myocardial infarction (AMI) is hindered by lack of engraftment of sufficient stem cells at the site of injury. We designed a novel technique to overcome this problem by assembling stem cell-microbubble complexes, named ‘StemBells’. StemBells were assembled through binding of dual-targeted microbubbles (~ 3 μm) to adipose-derived stem cells (ASCs) via a CD90 antibody. StemBells were targeted to the infarct area via an ICAM-1 antibody on the microbubbles. StemBells were characterized microscopically and by flow cytometry. The effect of ultrasound on directing StemBells towards the vessel wall was demonstrated in an in vitro flow model. In a rat AMI-reperfusion model, StemBells or ASCs were injected one week post-infarction. A pilot study demonstrated feasibility of intravenous StemBell injection, resulting in localization in ICAM-1-positive infarct area three hours post-injection. In a functional study five weeks after injection of StemBells cardiac function was significantly improved compared with controls, as monitored by 2D-echocardiography. This functional improvement neither coincided with a reduction in infarct size as determined by histochemical analysis, nor with a change in anti- and pro-inflammatory macrophages. In conclusion, the StemBell technique is a novel and feasible method, able to improve cardiac function post-AMI in rats." @default.
• W2344494025 created "2016-06-24" @default.
• W2344494025 creator A5004518590 @default.
• W2344494025 creator A5013753749 @default.
• W2344494025 creator A5018504789 @default.
• W2344494025 creator A5018662202 @default.
• W2344494025 creator A5022522937 @default.
• W2344494025 creator A5023689770 @default.
• W2344494025 creator A5027056106 @default.
• W2344494025 creator A5030294560 @default.
• W2344494025 creator A5043737347 @default.
• W2344494025 creator A5048392521 @default.
• W2344494025 creator A5052385185 @default.
• W2344494025 creator A5055872647 @default.
• W2344494025 creator A5055882699 @default.
• W2344494025 creator A5062434400 @default.
• W2344494025 creator A5065709060 @default.
• W2344494025 creator A5065784242 @default.
• W2344494025 creator A5066934405 @default.
• W2344494025 creator A5083354719 @default.
• W2344494025 date "2016-07-01" @default.
• W2344494025 modified "2023-09-27" @default.
• W2344494025 title "Development of a new therapeutic technique to direct stem cells to the infarcted heart using targeted microbubbles: StemBells" @default.
• W2344494025 cites W1851857875 @default.
• W2344494025 cites W1969380255 @default.
• W2344494025 cites W1994451429 @default.
• W2344494025 cites W1994734582 @default.
• W2344494025 cites W2015654015 @default.
• W2344494025 cites W2016519121 @default.
• W2344494025 cites W2018830839 @default.
• W2344494025 cites W2021586120 @default.
• W2344494025 cites W2021862643 @default.
• W2344494025 cites W2023494017 @default.
• W2344494025 cites W2025350376 @default.
• W2344494025 cites W2034488652 @default.
• W2344494025 cites W2035904396 @default.
• W2344494025 cites W2045911549 @default.
• W2344494025 cites W2054095354 @default.
• W2344494025 cites W2062550720 @default.
• W2344494025 cites W2068918386 @default.
• W2344494025 cites W2071419168 @default.
• W2344494025 cites W2071700707 @default.
• W2344494025 cites W2085526349 @default.
• W2344494025 cites W2086980194 @default.
• W2344494025 cites W2090193322 @default.
• W2344494025 cites W2092756213 @default.
• W2344494025 cites W2095522755 @default.
• W2344494025 cites W2097917938 @default.
• W2344494025 cites W2106457767 @default.
• W2344494025 cites W2113295978 @default.
• W2344494025 cites W2115284457 @default.
• W2344494025 cites W2124396531 @default.
• W2344494025 cites W2125635123 @default.
• W2344494025 cites W2133242615 @default.
• W2344494025 cites W2134070522 @default.
• W2344494025 cites W2137444894 @default.
• W2344494025 cites W2148468651 @default.
• W2344494025 cites W2149685956 @default.
• W2344494025 cites W2151722542 @default.
• W2344494025 cites W2155533706 @default.
• W2344494025 cites W2162255657 @default.
• W2344494025 cites W2164064356 @default.
• W2344494025 cites W2171099372 @default.
• W2344494025 cites W2399228814 @default.
• W2344494025 doi "https://doi.org/10.1016/j.scr.2016.04.018" @default.
• W2344494025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27186654" @default.
• W2344494025 hasPublicationYear "2016" @default.
• W2344494025 type Work @default.
• W2344494025 sameAs 2344494025 @default.
• W2344494025 citedByCount "22" @default.
• W2344494025 countsByYear W23444940252017 @default.
• W2344494025 countsByYear W23444940252018 @default.
• W2344494025 countsByYear W23444940252019 @default.
• W2344494025 countsByYear W23444940252020 @default.
• W2344494025 countsByYear W23444940252021 @default.
• W2344494025 countsByYear W23444940252022 @default.
• W2344494025 countsByYear W23444940252023 @default.
• W2344494025 crossrefType "journal-article" @default.
• W2344494025 hasAuthorship W2344494025A5004518590 @default.
• W2344494025 hasAuthorship W2344494025A5013753749 @default.
• W2344494025 hasAuthorship W2344494025A5018504789 @default.
• W2344494025 hasAuthorship W2344494025A5018662202 @default.
• W2344494025 hasAuthorship W2344494025A5022522937 @default.
• W2344494025 hasAuthorship W2344494025A5023689770 @default.
• W2344494025 hasAuthorship W2344494025A5027056106 @default.
• W2344494025 hasAuthorship W2344494025A5030294560 @default.
• W2344494025 hasAuthorship W2344494025A5043737347 @default.
• W2344494025 hasAuthorship W2344494025A5048392521 @default.
• W2344494025 hasAuthorship W2344494025A5052385185 @default.
• W2344494025 hasAuthorship W2344494025A5055872647 @default.
• W2344494025 hasAuthorship W2344494025A5055882699 @default.
• W2344494025 hasAuthorship W2344494025A5062434400 @default.
• W2344494025 hasAuthorship W2344494025A5065709060 @default.
• W2344494025 hasAuthorship W2344494025A5065784242 @default.
• W2344494025 hasAuthorship W2344494025A5066934405 @default.
• W2344494025 hasAuthorship W2344494025A5083354719 @default.
• W2344494025 hasBestOaLocation W23444940251 @default.
• W2344494025 hasConcept C10205521 @default.

• next