FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344523925> ?p ?o ?g. }

• W2344523925 endingPage "81" @default.
• W2344523925 startingPage "72" @default.
• W2344523925 abstract "1,2,3,4,6-Pentakis[-O-(3,4,5-trihydroxybenzoyl)]-α,β-D-glucopyranose (PGG) 12 has been reported for its antioxidant activities, where the free OH groups in PGG seem to be critical for activities. To explore PGG-based compounds as chemotherapeutic agents and to analyze the contribution of specific OH groups in PGG for anti-cancer activities, we designed and synthesized a series of 27 benzoic and cinnamic acid analogs of PGG. These analogs were tested for cytotoxicities against two human lung (A549 and H1299) and two human colon (HCT116 and HT29) cancer cell lines. Compound 12 (PGG) had highest cytotoxicities against HCT116 and A549 cells with IC50 of 1.61 µM and 3.02 µM, respectively. In contrast, the compound 16 (1,2,3,4,6-pentakis[-O-(4-hydroxy-3-methoxybenzoyl)]-α,β-D-glucopyranose, PVG) was most effective at killing HT29 and H1299 cells with IC50 of 1.76 µM and 3.65 µM, respectively, indicating the mutual contribution of m-methoxy and p-hydroxy groups to the observed cytotoxicities. Moreover, cinnamic acid analogs were less active than the benzoic acid analogs evidenced by higher IC50 values. Furthermore, in cinnamic acid analogs the hydrogenation of double bond to saturated 2-C side chain enhance the cytotoxicities in all four cell lines. Compounds also possess good anti-oxidant and reducing activities. Compound 12 and 26 show the highest antioxidant and reducing activities." @default.
• W2344523925 created "2016-06-24" @default.
• W2344523925 creator A5009561339 @default.
• W2344523925 creator A5013164209 @default.
• W2344523925 creator A5058920794 @default.
• W2344523925 creator A5061364907 @default.
• W2344523925 creator A5066986885 @default.
• W2344523925 creator A5078195957 @default.
• W2344523925 creator A5078526337 @default.
• W2344523925 creator A5079336629 @default.
• W2344523925 creator A5087057004 @default.
• W2344523925 date "2016-07-01" @default.
• W2344523925 modified "2023-10-16" @default.
• W2344523925 title "1,2,3,4,6-Pentakis[-O-(3,4,5-trihydroxybenzoyl)]-α,β-D-glucopyranose (PGG) analogs: design, synthesis, anti-tumor and anti-oxidant activities" @default.
• W2344523925 cites W1823911219 @default.
• W2344523925 cites W1969147804 @default.
• W2344523925 cites W1969754151 @default.
• W2344523925 cites W1980800729 @default.
• W2344523925 cites W1980882217 @default.
• W2344523925 cites W1996860534 @default.
• W2344523925 cites W1999268826 @default.
• W2344523925 cites W2007489502 @default.
• W2344523925 cites W2010575379 @default.
• W2344523925 cites W2021995332 @default.
• W2344523925 cites W2026629293 @default.
• W2344523925 cites W2027785477 @default.
• W2344523925 cites W202963727 @default.
• W2344523925 cites W2030880582 @default.
• W2344523925 cites W2032004441 @default.
• W2344523925 cites W2040400809 @default.
• W2344523925 cites W2042856747 @default.
• W2344523925 cites W2044857896 @default.
• W2344523925 cites W2066210051 @default.
• W2344523925 cites W2070302854 @default.
• W2344523925 cites W2071547862 @default.
• W2344523925 cites W2081731746 @default.
• W2344523925 cites W2086959952 @default.
• W2344523925 cites W2093947102 @default.
• W2344523925 cites W2103109755 @default.
• W2344523925 cites W2107219837 @default.
• W2344523925 cites W2152378482 @default.
• W2344523925 cites W2154105741 @default.
• W2344523925 cites W2159363927 @default.
• W2344523925 cites W2165631481 @default.
• W2344523925 cites W2168041765 @default.
• W2344523925 cites W2181805683 @default.
• W2344523925 cites W2312386925 @default.
• W2344523925 cites W2951129267 @default.
• W2344523925 doi "https://doi.org/10.1016/j.carres.2016.04.021" @default.
• W2344523925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27196315" @default.
• W2344523925 hasPublicationYear "2016" @default.
• W2344523925 type Work @default.
• W2344523925 sameAs 2344523925 @default.
• W2344523925 citedByCount "23" @default.
• W2344523925 countsByYear W23445239252017 @default.
• W2344523925 countsByYear W23445239252018 @default.
• W2344523925 countsByYear W23445239252019 @default.
• W2344523925 countsByYear W23445239252020 @default.
• W2344523925 countsByYear W23445239252021 @default.
• W2344523925 countsByYear W23445239252022 @default.
• W2344523925 countsByYear W23445239252023 @default.
• W2344523925 crossrefType "journal-article" @default.
• W2344523925 hasAuthorship W2344523925A5009561339 @default.
• W2344523925 hasAuthorship W2344523925A5013164209 @default.
• W2344523925 hasAuthorship W2344523925A5058920794 @default.
• W2344523925 hasAuthorship W2344523925A5061364907 @default.
• W2344523925 hasAuthorship W2344523925A5066986885 @default.
• W2344523925 hasAuthorship W2344523925A5078195957 @default.
• W2344523925 hasAuthorship W2344523925A5078526337 @default.
• W2344523925 hasAuthorship W2344523925A5079336629 @default.
• W2344523925 hasAuthorship W2344523925A5087057004 @default.
• W2344523925 hasConcept C178790620 @default.
• W2344523925 hasConcept C185592680 @default.
• W2344523925 hasConcept C202751555 @default.
• W2344523925 hasConcept C2777752497 @default.
• W2344523925 hasConcept C2778004101 @default.
• W2344523925 hasConcept C2778831176 @default.
• W2344523925 hasConcept C2778844314 @default.
• W2344523925 hasConcept C55493867 @default.
• W2344523925 hasConcept C71240020 @default.
• W2344523925 hasConcept C81729549 @default.
• W2344523925 hasConceptScore W2344523925C178790620 @default.
• W2344523925 hasConceptScore W2344523925C185592680 @default.
• W2344523925 hasConceptScore W2344523925C202751555 @default.
• W2344523925 hasConceptScore W2344523925C2777752497 @default.
• W2344523925 hasConceptScore W2344523925C2778004101 @default.
• W2344523925 hasConceptScore W2344523925C2778831176 @default.
• W2344523925 hasConceptScore W2344523925C2778844314 @default.
• W2344523925 hasConceptScore W2344523925C55493867 @default.
• W2344523925 hasConceptScore W2344523925C71240020 @default.
• W2344523925 hasConceptScore W2344523925C81729549 @default.
• W2344523925 hasFunder F4320321001 @default.
• W2344523925 hasLocation W23445239251 @default.
• W2344523925 hasLocation W23445239252 @default.
• W2344523925 hasLocation W23445239253 @default.
• W2344523925 hasLocation W23445239254 @default.
• W2344523925 hasOpenAccess W2344523925 @default.
• W2344523925 hasPrimaryLocation W23445239251 @default.

• next