FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344537348> ?p ?o ?g. }

• W2344537348 endingPage "1498" @default.
• W2344537348 startingPage "1491" @default.
• W2344537348 abstract "In recent years there has been an increase in the number of biomarkers in heart failure (HF). The clinical role for these novel biomarkers in combination is not clear.The following novel biomarkers were measured from 628 patients recently hospitalized with decompensated HF; mid-regional pro-adrenomedullin (MR-proADM), mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, high-sensitivity cardiac troponin T (hs-cTnT), ST2, galectin-3, cystatin C, combined free light chains (cFLC) and high sensitivity C-reactive protein (hsCRP). The incremental prognostic value of these novel biomarkers was evaluated within an extensive model containing established predictors of mortality. During a mean (SD) follow-up of 3.2 (1.5) years, 290 (46%) patients died. Elevated concentrations of all novel biomarkers were associated with an increased unadjusted risk of mortality but only two-thirds were independent predictors following multivariable analysis. Using dichotomized cut-points from receiver operating characteristic analysis, MR-proADM, hs-cTnT, cFLC, hsCRP, and ST2 remained independent predictors of mortality. Further dichotomization into low (0-2 elevated biomarkers) or high (at least three of the five biomarkers elevated) risk groups provided greatest incremental prognostic value (hazard ratio 2.20, 95% confidence interval 1.37-3.54; P = 0.001) and improved the performance of the model (C-statistic 0.730 from 0.721, net reclassification index 32.5%).The novel biomarkers included in this study added little, if any, incremental prognostic value on their own to a model containing established predictors of mortality. However, following dichotomization, five of the novel biomarkers provided incremental prognostic value. There was a clear gradient in the risk of death with increasing numbers of elevated novel biomarkers, with the presence of at least three identifying patients at greatest risk of mortality." @default.
• W2344537348 created "2016-06-24" @default.
• W2344537348 creator A5003943960 @default.
• W2344537348 creator A5009535057 @default.
• W2344537348 creator A5020717496 @default.
• W2344537348 creator A5021225266 @default.
• W2344537348 creator A5027213857 @default.
• W2344537348 creator A5034402860 @default.
• W2344537348 creator A5038999177 @default.
• W2344537348 creator A5039985378 @default.
• W2344537348 creator A5044064931 @default.
• W2344537348 creator A5067920658 @default.
• W2344537348 creator A5078354802 @default.
• W2344537348 creator A5078498803 @default.
• W2344537348 date "2016-04-25" @default.
• W2344537348 modified "2023-10-18" @default.
• W2344537348 title "The incremental prognostic and clinical value of multiple novel biomarkers in heart failure" @default.
• W2344537348 cites W1488720446 @default.
• W2344537348 cites W1976430849 @default.
• W2344537348 cites W1984775204 @default.
• W2344537348 cites W1996710573 @default.
• W2344537348 cites W2039669614 @default.
• W2344537348 cites W2046774168 @default.
• W2344537348 cites W2081438731 @default.
• W2344537348 cites W2099610554 @default.
• W2344537348 cites W2106421416 @default.
• W2344537348 cites W2109108463 @default.
• W2344537348 cites W2112316706 @default.
• W2344537348 cites W2122622124 @default.
• W2344537348 cites W2123664981 @default.
• W2344537348 cites W2126495538 @default.
• W2344537348 cites W2127039247 @default.
• W2344537348 cites W2129925362 @default.
• W2344537348 cites W2140162404 @default.
• W2344537348 cites W2148910374 @default.
• W2344537348 cites W2152865365 @default.
• W2344537348 cites W861869834 @default.
• W2344537348 doi "https://doi.org/10.1002/ejhf.543" @default.
• W2344537348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27114189" @default.
• W2344537348 hasPublicationYear "2016" @default.
• W2344537348 type Work @default.
• W2344537348 sameAs 2344537348 @default.
• W2344537348 citedByCount "51" @default.
• W2344537348 countsByYear W23445373482016 @default.
• W2344537348 countsByYear W23445373482017 @default.
• W2344537348 countsByYear W23445373482018 @default.
• W2344537348 countsByYear W23445373482019 @default.
• W2344537348 countsByYear W23445373482020 @default.
• W2344537348 countsByYear W23445373482021 @default.
• W2344537348 countsByYear W23445373482022 @default.
• W2344537348 countsByYear W23445373482023 @default.
• W2344537348 crossrefType "journal-article" @default.
• W2344537348 hasAuthorship W2344537348A5003943960 @default.
• W2344537348 hasAuthorship W2344537348A5009535057 @default.
• W2344537348 hasAuthorship W2344537348A5020717496 @default.
• W2344537348 hasAuthorship W2344537348A5021225266 @default.
• W2344537348 hasAuthorship W2344537348A5027213857 @default.
• W2344537348 hasAuthorship W2344537348A5034402860 @default.
• W2344537348 hasAuthorship W2344537348A5038999177 @default.
• W2344537348 hasAuthorship W2344537348A5039985378 @default.
• W2344537348 hasAuthorship W2344537348A5044064931 @default.
• W2344537348 hasAuthorship W2344537348A5067920658 @default.
• W2344537348 hasAuthorship W2344537348A5078354802 @default.
• W2344537348 hasAuthorship W2344537348A5078498803 @default.
• W2344537348 hasBestOaLocation W23445373481 @default.
• W2344537348 hasConcept C126322002 @default.
• W2344537348 hasConcept C164705383 @default.
• W2344537348 hasConcept C207103383 @default.
• W2344537348 hasConcept C2775915353 @default.
• W2344537348 hasConcept C2776370428 @default.
• W2344537348 hasConcept C2778198053 @default.
• W2344537348 hasConcept C2779311642 @default.
• W2344537348 hasConcept C2779548226 @default.
• W2344537348 hasConcept C2780306776 @default.
• W2344537348 hasConcept C36036425 @default.
• W2344537348 hasConcept C44249647 @default.
• W2344537348 hasConcept C500558357 @default.
• W2344537348 hasConcept C50382708 @default.
• W2344537348 hasConcept C71924100 @default.
• W2344537348 hasConceptScore W2344537348C126322002 @default.
• W2344537348 hasConceptScore W2344537348C164705383 @default.
• W2344537348 hasConceptScore W2344537348C207103383 @default.
• W2344537348 hasConceptScore W2344537348C2775915353 @default.
• W2344537348 hasConceptScore W2344537348C2776370428 @default.
• W2344537348 hasConceptScore W2344537348C2778198053 @default.
• W2344537348 hasConceptScore W2344537348C2779311642 @default.
• W2344537348 hasConceptScore W2344537348C2779548226 @default.
• W2344537348 hasConceptScore W2344537348C2780306776 @default.
• W2344537348 hasConceptScore W2344537348C36036425 @default.
• W2344537348 hasConceptScore W2344537348C44249647 @default.
• W2344537348 hasConceptScore W2344537348C500558357 @default.
• W2344537348 hasConceptScore W2344537348C50382708 @default.
• W2344537348 hasConceptScore W2344537348C71924100 @default.
• W2344537348 hasIssue "12" @default.
• W2344537348 hasLocation W23445373481 @default.
• W2344537348 hasLocation W23445373482 @default.
• W2344537348 hasLocation W23445373483 @default.
• W2344537348 hasOpenAccess W2344537348 @default.

• next