FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344613001> ?p ?o ?g. }

• W2344613001 endingPage "97" @default.
• W2344613001 startingPage "89" @default.
• W2344613001 abstract "Tooth extraction causes bone resorption of the alveolar bone volume. Although recombinant human bone morphogenetic protein 2 (rhBMP-2) markedly promotes de novo bone formation after tooth extraction, the application of high-dose rhBMP-2 may induce side effects, such as swelling, seroma, and an increased cancer risk. Therefore, reduction of the necessary dose of rhBMP-2 which can still obtain sufficient bone mass is necessary by developing a new osteogenic reagent. Recently, we showed that the systemic administration of OP3-4 peptide, which was originally designed as a bone resorption inhibitor, had osteogenic ability both in vitro and in vivo. This study evaluated the ability of the local application of OP3-4 peptide to promote bone formation in a murine tooth extraction model with a very low-dose of BMP. The mandibular incisor was extracted from 10-week-old C57BL6/J male mice and a gelatin hydrogel containing rhBMP-2 with or without OP3-4 peptide (BMP/OP3-4) was applied to the socket of the incisor. Bone formation inside the socket was examined radiologically and histologically at 21 days after the extraction. The BMP/OP3-4-group showed significant bone formation inside the mandibular extraction socket compared to the gelatin-hydrogel-carrier-control group or rhBMP-2-applied group. The BMP/OP3-4-applied mice showed a lower reduction of alveolar bone and fewer osteoclast numbers, suggesting that the newly formed bone inside the socket may prevent resorption of the cortical bone around the extraction socket. Our data revealed that OP3-4 peptide promotes BMP-mediated bone formation inside the extraction socket of mandibular bone, resulting in preservation from the loss of alveolar bone." @default.
• W2344613001 created "2016-06-24" @default.
• W2344613001 creator A5001874444 @default.
• W2344613001 creator A5007612676 @default.
• W2344613001 creator A5011463200 @default.
• W2344613001 creator A5020629148 @default.
• W2344613001 creator A5055033211 @default.
• W2344613001 creator A5079999941 @default.
• W2344613001 creator A5080875747 @default.
• W2344613001 creator A5081630696 @default.
• W2344613001 date "2016-07-01" @default.
• W2344613001 modified "2023-10-17" @default.
• W2344613001 title "Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model" @default.
• W2344613001 cites W1842355645 @default.
• W2344613001 cites W1980308012 @default.
• W2344613001 cites W1985108202 @default.
• W2344613001 cites W1995226135 @default.
• W2344613001 cites W1996682859 @default.
• W2344613001 cites W1999943656 @default.
• W2344613001 cites W2008943389 @default.
• W2344613001 cites W2014861948 @default.
• W2344613001 cites W2015329065 @default.
• W2344613001 cites W2021274422 @default.
• W2344613001 cites W2021804974 @default.
• W2344613001 cites W2024127570 @default.
• W2344613001 cites W2028079449 @default.
• W2344613001 cites W2032610354 @default.
• W2344613001 cites W2032772487 @default.
• W2344613001 cites W2036939647 @default.
• W2344613001 cites W2039065761 @default.
• W2344613001 cites W2048299560 @default.
• W2344613001 cites W2057997905 @default.
• W2344613001 cites W2064273201 @default.
• W2344613001 cites W2065221593 @default.
• W2344613001 cites W2068509737 @default.
• W2344613001 cites W2069562979 @default.
• W2344613001 cites W2071559424 @default.
• W2344613001 cites W2073112480 @default.
• W2344613001 cites W2074552199 @default.
• W2344613001 cites W2085538354 @default.
• W2344613001 cites W2096425957 @default.
• W2344613001 cites W2106751714 @default.
• W2344613001 cites W2110166708 @default.
• W2344613001 cites W2111579339 @default.
• W2344613001 cites W2115075530 @default.
• W2344613001 cites W2118089919 @default.
• W2344613001 cites W2123028746 @default.
• W2344613001 cites W2133081899 @default.
• W2344613001 cites W2137169302 @default.
• W2344613001 cites W2139996507 @default.
• W2344613001 cites W2164820929 @default.
• W2344613001 cites W2165050339 @default.
• W2344613001 cites W2174726620 @default.
• W2344613001 cites W2176716502 @default.
• W2344613001 cites W2465295019 @default.
• W2344613001 doi "https://doi.org/10.1016/j.ejphar.2016.04.049" @default.
• W2344613001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27118173" @default.
• W2344613001 hasPublicationYear "2016" @default.
• W2344613001 type Work @default.
• W2344613001 sameAs 2344613001 @default.
• W2344613001 citedByCount "11" @default.
• W2344613001 countsByYear W23446130012018 @default.
• W2344613001 countsByYear W23446130012019 @default.
• W2344613001 countsByYear W23446130012020 @default.
• W2344613001 countsByYear W23446130012021 @default.
• W2344613001 countsByYear W23446130012022 @default.
• W2344613001 countsByYear W23446130012023 @default.
• W2344613001 crossrefType "journal-article" @default.
• W2344613001 hasAuthorship W2344613001A5001874444 @default.
• W2344613001 hasAuthorship W2344613001A5007612676 @default.
• W2344613001 hasAuthorship W2344613001A5011463200 @default.
• W2344613001 hasAuthorship W2344613001A5020629148 @default.
• W2344613001 hasAuthorship W2344613001A5055033211 @default.
• W2344613001 hasAuthorship W2344613001A5079999941 @default.
• W2344613001 hasAuthorship W2344613001A5080875747 @default.
• W2344613001 hasAuthorship W2344613001A5081630696 @default.
• W2344613001 hasConcept C126322002 @default.
• W2344613001 hasConcept C146562846 @default.
• W2344613001 hasConcept C151279780 @default.
• W2344613001 hasConcept C185592680 @default.
• W2344613001 hasConcept C199343813 @default.
• W2344613001 hasConcept C202751555 @default.
• W2344613001 hasConcept C2776033226 @default.
• W2344613001 hasConcept C55493867 @default.
• W2344613001 hasConcept C673006 @default.
• W2344613001 hasConcept C71924100 @default.
• W2344613001 hasConceptScore W2344613001C126322002 @default.
• W2344613001 hasConceptScore W2344613001C146562846 @default.
• W2344613001 hasConceptScore W2344613001C151279780 @default.
• W2344613001 hasConceptScore W2344613001C185592680 @default.
• W2344613001 hasConceptScore W2344613001C199343813 @default.
• W2344613001 hasConceptScore W2344613001C202751555 @default.
• W2344613001 hasConceptScore W2344613001C2776033226 @default.
• W2344613001 hasConceptScore W2344613001C55493867 @default.
• W2344613001 hasConceptScore W2344613001C673006 @default.
• W2344613001 hasConceptScore W2344613001C71924100 @default.
• W2344613001 hasFunder F4320320212 @default.
• W2344613001 hasLocation W23446130011 @default.

• next