Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344667025> ?p ?o ?g. }
- W2344667025 abstract "The biological effects of microRNAs (miRNAs) in the Fragile X Syndrome (FXS) have been widely studied. Dysregulation of miRNAs plays a critical role in the progression of nervous system diseases and in cell proliferation and differentiation. Our previous study validated that miR-19b-3p was associated with FXR1 (Fragile X related gene 1), one of homologous genes of FMR1 (Fragile X mental retardation 1). The purpose of this study was to investigate the relationship of FXR1 and miR-19b-3p, and the crucial role of miR-19b-3p in FXS and to validate whether miR-19b-3p could regulate the growth of SH-SY5Y cells. We determined that miR-19b-3p could regulate the expression of not only USP32, RAB18 and Dusp6 but also FXR1, and FXR1 could in turn regulate the expression of miR-19b-3p. What's more, the overexpression of miR-19b-3p significantly inhibited the proliferation, contributed the apoptosis and slowed down the cycle of SH-SY5Y cells. Taken together, our results indicate that miR-19b-3p plays a significant role in the molecular pathology of FXS by interacting with FXR1 and influencing the growth of SH-SY5Y cells." @default.
- W2344667025 created "2016-06-24" @default.
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- W2344667025 date "2016-08-01" @default.
- W2344667025 modified "2023-09-29" @default.
- W2344667025 title "The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y" @default.
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- W2344667025 doi "https://doi.org/10.1016/j.gene.2016.04.037" @default.
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