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• W2344681272 abstract "The migration, survival and proliferation of cells is the basis for all physiologic and pathologic pro- cesses in the human body. All these reactions are regulated by a complex chemokine network that guides lym- phocytes homing, chemotaxis, adhesion and interplay between immunologic system response cells. Chemokines are also responsible for metastatic dissemination of cancers, including Hodgkin's and non-Hodgkin's lympho- mas. The purpose of this study was to determine chemokine gene expression (CXCL8, CXCL10, CCL2, CCL3, CCL4 and CCL5) in lymphoma lymph nodes compared to their expression in reactive lymph nodes. We also analyzed the influence of chemokine gene expression on the survival of lymphoma patients. Chemokine gene expression was evaluated in 37 lymphoma lymph nodes and in 25 samples of reactive lymph nodes. Gene expres- sion of chemokines CXCL8, CXCL10, CCL2, CCL3, CCL4 and CCL5 was measured using the PCR method. Statistical analysis was performed using CSS Statistica for Windows (version 7.0) software. Probability values < < 0.05 were considered statistically significant and those between 0.05 and 0.1 as indicative of a trend. We found lower CXCL8 and CXCL10 gene expression in lymphoma lymph nodes compared to reactive lymph nodes. In the cases of CCL2 and CCL3, expression in lymphomas was higher than in reactive lymph nodes. Patients with high expression of CCL2 and CXCL10 had shorter survival. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 2, pp. 240-247)" @default.
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• W2344681272 date "2011-01-01" @default.
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• W2344681272 title "P Proinflammatory chemokine gene expression roinflammatory chemokine gene expression roinflammatory chemokine gene expression roinflammatory chemokine gene expression roinflammatory chemokine gene expression influences survival of patients with influences survival of patients with influences survival of patients with influences survival of patients with influences survival of patients with non-Hodgkin's lymphoma non-Hodgkin's lymphoma non-Hodgkin's lymphoma non-Hodgkin's lymphoma non-Hodgkin's …" @default.
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• W2344681272 hasPublicationYear "2011" @default.
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