Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344740006> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2344740006 endingPage "E239" @default.
- W2344740006 startingPage "E234" @default.
- W2344740006 abstract "To examine the possible activation of prorenin in the circulation, recombinant rat prorenin was intravenously given to pentobarbital-anesthetized rats. Bolus injection of prorenin at the dose of 100 micrograms angiotensin I (ANG I).h-1.kg-1 into Wistar rats, leading to a 15-fold increase in plasma prorenin concentrations (from 27 +/- 6 to 393 +/- 75 ng ANG I.h-1.ml-1) at 5 min after the injection, did not affect blood pressure, heart rate, and plasma active renin concentrations throughout experiments. On the other hand, the administration of active renin at the dose of 1, 3, and 10 micrograms ANG I.h-1.kg-1 increased mean blood pressure of Wistar rats by 8 +/- 2, 15 +/- 2, and 27 +/- 4 mmHg, respectively. Similar results were obtained in Wistar rats at 18 h after bilateral nephrectomy. These results confirmed no activation of prorenin in the circulation of normotensive rats. The activation of prorenin was also examined on both stroke-prone spontaneously hypertensive rats (SHRSP) and 18 h-nephrectomized SHRSP. There was no rise in blood pressure or plasma active renin concentrations in both groups of SHRSP after injection of prorenin. Thus the elevated plasma active renin in SHRSP [Shibota, M., A. Nagaoka, A. Shino, and T. Fujita. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H409-H416, 1979] seems to be caused by the enhanced release of active renin from the kidney rather than the activation of circulating prorenin." @default.
- W2344740006 created "2016-06-24" @default.
- W2344740006 creator A5051420763 @default.
- W2344740006 creator A5055114429 @default.
- W2344740006 creator A5078107899 @default.
- W2344740006 creator A5079078976 @default.
- W2344740006 creator A5084096323 @default.
- W2344740006 creator A5084214689 @default.
- W2344740006 date "1992-02-01" @default.
- W2344740006 modified "2023-09-27" @default.
- W2344740006 title "Effects of prorenin on blood pressure and plasma renin concentrations in stroke-prone spontaneously hypertensive rats" @default.
- W2344740006 cites W1492834300 @default.
- W2344740006 cites W192672120 @default.
- W2344740006 cites W1967369441 @default.
- W2344740006 cites W1972554266 @default.
- W2344740006 cites W1991360681 @default.
- W2344740006 cites W1999234561 @default.
- W2344740006 cites W2000079271 @default.
- W2344740006 cites W2012007710 @default.
- W2344740006 cites W2027451328 @default.
- W2344740006 cites W2046688791 @default.
- W2344740006 cites W2086842916 @default.
- W2344740006 cites W2113415982 @default.
- W2344740006 cites W2139627824 @default.
- W2344740006 cites W2146721491 @default.
- W2344740006 cites W2148295690 @default.
- W2344740006 cites W2155014088 @default.
- W2344740006 cites W2319301074 @default.
- W2344740006 cites W2410345389 @default.
- W2344740006 cites W2469275897 @default.
- W2344740006 cites W3011553392 @default.
- W2344740006 doi "https://doi.org/10.1152/ajpendo.1992.262.2.e234" @default.
- W2344740006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1539651" @default.
- W2344740006 hasPublicationYear "1992" @default.
- W2344740006 type Work @default.
- W2344740006 sameAs 2344740006 @default.
- W2344740006 citedByCount "6" @default.
- W2344740006 crossrefType "journal-article" @default.
- W2344740006 hasAuthorship W2344740006A5051420763 @default.
- W2344740006 hasAuthorship W2344740006A5055114429 @default.
- W2344740006 hasAuthorship W2344740006A5078107899 @default.
- W2344740006 hasAuthorship W2344740006A5079078976 @default.
- W2344740006 hasAuthorship W2344740006A5084096323 @default.
- W2344740006 hasAuthorship W2344740006A5084214689 @default.
- W2344740006 hasConcept C126322002 @default.
- W2344740006 hasConcept C134018914 @default.
- W2344740006 hasConcept C138976137 @default.
- W2344740006 hasConcept C150903083 @default.
- W2344740006 hasConcept C185592680 @default.
- W2344740006 hasConcept C198710026 @default.
- W2344740006 hasConcept C207001950 @default.
- W2344740006 hasConcept C2776755955 @default.
- W2344740006 hasConcept C2780091579 @default.
- W2344740006 hasConcept C2780227381 @default.
- W2344740006 hasConcept C71924100 @default.
- W2344740006 hasConcept C84393581 @default.
- W2344740006 hasConcept C86803240 @default.
- W2344740006 hasConceptScore W2344740006C126322002 @default.
- W2344740006 hasConceptScore W2344740006C134018914 @default.
- W2344740006 hasConceptScore W2344740006C138976137 @default.
- W2344740006 hasConceptScore W2344740006C150903083 @default.
- W2344740006 hasConceptScore W2344740006C185592680 @default.
- W2344740006 hasConceptScore W2344740006C198710026 @default.
- W2344740006 hasConceptScore W2344740006C207001950 @default.
- W2344740006 hasConceptScore W2344740006C2776755955 @default.
- W2344740006 hasConceptScore W2344740006C2780091579 @default.
- W2344740006 hasConceptScore W2344740006C2780227381 @default.
- W2344740006 hasConceptScore W2344740006C71924100 @default.
- W2344740006 hasConceptScore W2344740006C84393581 @default.
- W2344740006 hasConceptScore W2344740006C86803240 @default.
- W2344740006 hasIssue "2" @default.
- W2344740006 hasLocation W23447400061 @default.
- W2344740006 hasLocation W23447400062 @default.
- W2344740006 hasOpenAccess W2344740006 @default.
- W2344740006 hasPrimaryLocation W23447400061 @default.
- W2344740006 hasRelatedWork W1969858557 @default.
- W2344740006 hasRelatedWork W1977123261 @default.
- W2344740006 hasRelatedWork W2044747643 @default.
- W2344740006 hasRelatedWork W2047608102 @default.
- W2344740006 hasRelatedWork W2077998387 @default.
- W2344740006 hasRelatedWork W2079602738 @default.
- W2344740006 hasRelatedWork W2080723551 @default.
- W2344740006 hasRelatedWork W2088924510 @default.
- W2344740006 hasRelatedWork W2475039109 @default.
- W2344740006 hasRelatedWork W2081968899 @default.
- W2344740006 hasVolume "262" @default.
- W2344740006 isParatext "false" @default.
- W2344740006 isRetracted "false" @default.
- W2344740006 magId "2344740006" @default.
- W2344740006 workType "article" @default.