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- W2344758974 abstract "Patients with PD scheduled for STN-DBS were recruited. They were tested in a satiated state before surgery in on medication, and after surgery in on medication/off stimulation and on medication/on stimulation. All participants were asked to complete a self-report questionnaire about impulsiveness, a go-no-go experiment measuring the response inhibition to food items and finally, a task that evaluates hedonic and motivational aspects of food processing (liking and wanting, respectively). The preoperative and postoperative body weights were recorded. The mean body weight of patients increased postoperatively. Both reward sensitivity and impulsivity increased after surgery. The weight changes correlated positively with hedonic ratings of food items and salience/motivation towards foods in on medication/on stimulation, in particular for non-sweet foods (both high and low calorie foods). Moreover, weight changes correlated positively with false alarms for food items in the go no-go task in on medication/on stimulation. Finally, weight changes correlated negatively with motor impulsiveness in the pre surgical condition and positively with changes in motor impulsiveness after surgery. Our results confirm that STN-DBS expose patients to the risk of weight gain. Moreover, they suggest that postoperative weight gain may be related to changes in food reward sensitivity and in inhibitory control. Both these aspects have been recognized to play an important role in eating behaviors." @default.
- W2344758974 created "2016-06-24" @default.
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- W2344758974 date "2015-01-01" @default.
- W2344758974 modified "2023-09-27" @default.
- W2344758974 title "A possible role of reward sensitivity and impulsivity in weight gain after deep brain stimulation." @default.
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