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- W2344804652 abstract "Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for the development of norovirus therapeutics entails the discovery of inhibitors of norovirus 3CL protease, an enzyme essential for noroviral replication. We describe herein the structure-based design of the first class of permeable, triazole-based macrocyclic inhibitors of norovirus 3C-like protease, as well as pertinent X-ray crystallographic, biochemical, spectroscopic, and antiviral studies." @default.
- W2344804652 created "2016-06-24" @default.
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- W2344804652 date "2016-08-01" @default.
- W2344804652 modified "2023-09-28" @default.
- W2344804652 title "Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies" @default.
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- W2344804652 doi "https://doi.org/10.1016/j.ejmech.2016.04.013" @default.
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