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• W2344884473 startingPage "14" @default.
• W2344884473 abstract "Acne vulgaris (commonly called acne) is a most common skin disease during adolescence, afflicting more than 85% of teenagers. Topical tetracycline (Tc) is used for mild inflammatory acne and as an adjunct to systemic treatment in more severe forms. Solid lipid microparticles (SLMs) are useful tool for topical delivery because of their biodegradable, biocompatible and low toxic characteristic accompanying with excellent skin hydration, occlusiveness and controlled release properties. The purpose of this study was to prepare Tc-loaded SLMs were produced by the spray drying technique and characterized by scanning electron microscopy, powder X-ray diffractometry and differential scanning calorimetry. In vitro and ex vivo release characteristics of Tc through SLMs and control formulations (aqueous carbopol gel) were evaluated over 24 h using a vertical Franz diffusion cell through cellulose acetate membranes and exercised rat skin, respectively. SLM formulations present high encapsulation values above 97% without significant different among formulations (p < 0.05). The sustained release pattern of Tc through SLMs was illustrated by in vitro release study. The ex vivo drug skin permeation study revealed that Tc dermal deposition of optimum SLMs formulation was about 7 times that of the control formulations. The enhanced skin penetration and accumulation of Tc observed for Tc-loaded SLMs may increase the efficiency of acne therapy and decrease the associated Tc side effects." @default.
• W2344884473 created "2016-06-24" @default.
• W2344884473 creator A5006145152 @default.
• W2344884473 creator A5043708378 @default.
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• W2344884473 date "2016-09-01" @default.
• W2344884473 modified "2023-09-30" @default.
• W2344884473 title "Solid lipid microparticles for enhanced dermal delivery of tetracycline HCl" @default.
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• W2344884473 doi "https://doi.org/10.1016/j.colsurfb.2016.04.034" @default.
• W2344884473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27131093" @default.
• W2344884473 hasPublicationYear "2016" @default.
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