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- W2344898340 abstract "Radiopharmacological investigations of [18F]NS14490 have proven that this radiotracer could be a potential PET radiotracer for imaging of alpha7 nicotinic acetylcholine receptor particularly with regard to vulnerable plaques of diseased vessels. For further optimisation of the previously automated one-pot radiosynthesis of [18F]NS14490 using a tosylate precursor, precursors with other leaving groups (nosylate and mosylate) were synthesized and compared with the tosylate with respect to their reactivities towards [18F]fluoride. The use of these different precursors resulted in comparable labelling yields of [18F]NS14490. A novel mosylate precursor was synthesized and evaluated, which has revealed a higher stability during a storage period of five months compared to the corresponding tosylate and nosylate." @default.
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- W2344898340 date "2016-08-01" @default.
- W2344898340 modified "2023-09-27" @default.
- W2344898340 title "Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [18F]NS14490" @default.
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- W2344898340 doi "https://doi.org/10.1016/j.apradiso.2016.04.028" @default.
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