FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344907098> ?p ?o ?g. }

• W2344907098 abstract "Background & Aims: Confocal endomicroscopy is an emerging technology that poses the endoscopist with challenges for identifying epithelial structures in the human intestine. We have shown previously that the murine intestinal epithelium is punctuated by gaps caused by cell shedding. The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding. Methods: Intestinal mucosa was imaged after staining with acriflavine. Confocal endomicroscopy of 17 patients yielded 6277 images from the human terminal ileum and rectum. Results were validated by parallel studies of anesthetized mice (wild-type and Math1 Intestine ) using rigid confocal probe microscopy, 2-photon/confocal microscopy, and scanning electron microscopy. Results: Human terminal ileal and rectal epithelium revealed unstained areas with the diameter of an individual epithelial cell, with 2 distinct morphologies. One had a “target” appearance, shown by mouse studies to be goblet cells. The other morphology had no nucleus and was observed by rigid confocal probe microscopy and scanning electron microscopy in the villi of Math1 Intestine mice, which lack goblet cells. In the mouse, tumor necrosis factor (0.33 g/g intraperitoneally) increases cell shedding by 27-fold and caused loss of barrier function across 20% of resultant gaps. Conclusions: Confocal endomicroscopy can distinguish between epithelial discontinuities (gaps) and goblet cells in human intestine. Results suggest that the sealing of epithelial gaps must be considered as a component of the intestinal barrier and has potential implications for intestinal barrier dysfunction in human disease." @default.
• W2344907098 created "2016-06-24" @default.
• W2344907098 creator A5009112860 @default.
• W2344907098 creator A5032751641 @default.
• W2344907098 creator A5042250367 @default.
• W2344907098 creator A5049110134 @default.
• W2344907098 creator A5053251591 @default.
• W2344907098 creator A5053444208 @default.
• W2344907098 creator A5054348304 @default.
• W2344907098 creator A5057113572 @default.
• W2344907098 creator A5060915537 @default.
• W2344907098 creator A5063664853 @default.
• W2344907098 creator A5090252236 @default.
• W2344907098 date "2007-01-01" @default.
• W2344907098 modified "2023-09-24" @default.
• W2344907098 title "CLINICAL-ALIMENTARY TRACT Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy" @default.
• W2344907098 cites W1525871018 @default.
• W2344907098 cites W1901931884 @default.
• W2344907098 cites W1975523864 @default.
• W2344907098 cites W1985665104 @default.
• W2344907098 cites W1996543394 @default.
• W2344907098 cites W2000014801 @default.
• W2344907098 cites W2005690646 @default.
• W2344907098 cites W2006194008 @default.
• W2344907098 cites W2024121049 @default.
• W2344907098 cites W2060773534 @default.
• W2344907098 cites W2061791452 @default.
• W2344907098 cites W2064048008 @default.
• W2344907098 cites W2066967759 @default.
• W2344907098 cites W2067386697 @default.
• W2344907098 cites W2086618209 @default.
• W2344907098 cites W2114469936 @default.
• W2344907098 cites W2117374458 @default.
• W2344907098 cites W2121618677 @default.
• W2344907098 cites W2123711491 @default.
• W2344907098 cites W2124705707 @default.
• W2344907098 cites W2144537799 @default.
• W2344907098 cites W2148459495 @default.
• W2344907098 cites W2163742326 @default.
• W2344907098 cites W2321453230 @default.
• W2344907098 cites W2401388802 @default.
• W2344907098 cites W2414675254 @default.
• W2344907098 cites W401716956 @default.
• W2344907098 cites W67591758 @default.
• W2344907098 hasPublicationYear "2007" @default.
• W2344907098 type Work @default.
• W2344907098 sameAs 2344907098 @default.
• W2344907098 citedByCount "0" @default.
• W2344907098 crossrefType "journal-article" @default.
• W2344907098 hasAuthorship W2344907098A5009112860 @default.
• W2344907098 hasAuthorship W2344907098A5032751641 @default.
• W2344907098 hasAuthorship W2344907098A5042250367 @default.
• W2344907098 hasAuthorship W2344907098A5049110134 @default.
• W2344907098 hasAuthorship W2344907098A5053251591 @default.
• W2344907098 hasAuthorship W2344907098A5053444208 @default.
• W2344907098 hasAuthorship W2344907098A5054348304 @default.
• W2344907098 hasAuthorship W2344907098A5057113572 @default.
• W2344907098 hasAuthorship W2344907098A5060915537 @default.
• W2344907098 hasAuthorship W2344907098A5063664853 @default.
• W2344907098 hasAuthorship W2344907098A5090252236 @default.
• W2344907098 hasConcept C120665830 @default.
• W2344907098 hasConcept C121332964 @default.
• W2344907098 hasConcept C126322002 @default.
• W2344907098 hasConcept C134018914 @default.
• W2344907098 hasConcept C136009344 @default.
• W2344907098 hasConcept C142724271 @default.
• W2344907098 hasConcept C17480853 @default.
• W2344907098 hasConcept C2779178360 @default.
• W2344907098 hasConcept C3019368612 @default.
• W2344907098 hasConcept C529295009 @default.
• W2344907098 hasConcept C66090201 @default.
• W2344907098 hasConcept C71924100 @default.
• W2344907098 hasConcept C86803240 @default.
• W2344907098 hasConcept C95444343 @default.
• W2344907098 hasConceptScore W2344907098C120665830 @default.
• W2344907098 hasConceptScore W2344907098C121332964 @default.
• W2344907098 hasConceptScore W2344907098C126322002 @default.
• W2344907098 hasConceptScore W2344907098C134018914 @default.
• W2344907098 hasConceptScore W2344907098C136009344 @default.
• W2344907098 hasConceptScore W2344907098C142724271 @default.
• W2344907098 hasConceptScore W2344907098C17480853 @default.
• W2344907098 hasConceptScore W2344907098C2779178360 @default.
• W2344907098 hasConceptScore W2344907098C3019368612 @default.
• W2344907098 hasConceptScore W2344907098C529295009 @default.
• W2344907098 hasConceptScore W2344907098C66090201 @default.
• W2344907098 hasConceptScore W2344907098C71924100 @default.
• W2344907098 hasConceptScore W2344907098C86803240 @default.
• W2344907098 hasConceptScore W2344907098C95444343 @default.
• W2344907098 hasLocation W23449070981 @default.
• W2344907098 hasOpenAccess W2344907098 @default.
• W2344907098 hasPrimaryLocation W23449070981 @default.
• W2344907098 hasRelatedWork W1235823829 @default.
• W2344907098 hasRelatedWork W1967137957 @default.
• W2344907098 hasRelatedWork W1986233870 @default.
• W2344907098 hasRelatedWork W1993184653 @default.
• W2344907098 hasRelatedWork W2044202374 @default.
• W2344907098 hasRelatedWork W2071419797 @default.
• W2344907098 hasRelatedWork W2086618209 @default.
• W2344907098 hasRelatedWork W2093929434 @default.
• W2344907098 hasRelatedWork W2107931679 @default.

• next