Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344997664> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2344997664 endingPage "4398" @default.
- W2344997664 startingPage "4393" @default.
- W2344997664 abstract "The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step in the synthetic sequence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroacetone, giving rise to 4-(methoxycarbonyl)-5,5-disubstituted 2-oxazoline. A simple NMR-based determination of enantiomeric purity is also described." @default.
- W2344997664 created "2016-06-24" @default.
- W2344997664 creator A5003416661 @default.
- W2344997664 creator A5039280742 @default.
- W2344997664 creator A5050431034 @default.
- W2344997664 creator A5057878088 @default.
- W2344997664 creator A5086723077 @default.
- W2344997664 date "2016-05-06" @default.
- W2344997664 modified "2023-10-16" @default.
- W2344997664 title "A Scalable Synthesis of the Difluoromethyl-<i>allo</i>-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058" @default.
- W2344997664 cites W1972772985 @default.
- W2344997664 cites W1984611400 @default.
- W2344997664 cites W1992975768 @default.
- W2344997664 cites W2022288007 @default.
- W2344997664 cites W2025253673 @default.
- W2344997664 cites W2075384842 @default.
- W2344997664 cites W2097395772 @default.
- W2344997664 cites W2098997185 @default.
- W2344997664 cites W2115486016 @default.
- W2344997664 cites W2121531566 @default.
- W2344997664 cites W2123927544 @default.
- W2344997664 cites W2128179591 @default.
- W2344997664 cites W2143802904 @default.
- W2344997664 cites W2165496299 @default.
- W2344997664 cites W2296140671 @default.
- W2344997664 cites W2345978176 @default.
- W2344997664 cites W24568803 @default.
- W2344997664 cites W2949376468 @default.
- W2344997664 cites W2951061017 @default.
- W2344997664 doi "https://doi.org/10.1021/acs.joc.6b00589" @default.
- W2344997664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5164921" @default.
- W2344997664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27128325" @default.
- W2344997664 hasPublicationYear "2016" @default.
- W2344997664 type Work @default.
- W2344997664 sameAs 2344997664 @default.
- W2344997664 citedByCount "14" @default.
- W2344997664 countsByYear W23449976642016 @default.
- W2344997664 countsByYear W23449976642017 @default.
- W2344997664 countsByYear W23449976642018 @default.
- W2344997664 countsByYear W23449976642019 @default.
- W2344997664 countsByYear W23449976642020 @default.
- W2344997664 countsByYear W23449976642021 @default.
- W2344997664 countsByYear W23449976642023 @default.
- W2344997664 crossrefType "journal-article" @default.
- W2344997664 hasAuthorship W2344997664A5003416661 @default.
- W2344997664 hasAuthorship W2344997664A5039280742 @default.
- W2344997664 hasAuthorship W2344997664A5050431034 @default.
- W2344997664 hasAuthorship W2344997664A5057878088 @default.
- W2344997664 hasAuthorship W2344997664A5086723077 @default.
- W2344997664 hasBestOaLocation W23449976642 @default.
- W2344997664 hasConcept C161790260 @default.
- W2344997664 hasConcept C178790620 @default.
- W2344997664 hasConcept C185592680 @default.
- W2344997664 hasConcept C21951064 @default.
- W2344997664 hasConcept C2775944816 @default.
- W2344997664 hasConcept C486523 @default.
- W2344997664 hasConcept C61156836 @default.
- W2344997664 hasConcept C71240020 @default.
- W2344997664 hasConceptScore W2344997664C161790260 @default.
- W2344997664 hasConceptScore W2344997664C178790620 @default.
- W2344997664 hasConceptScore W2344997664C185592680 @default.
- W2344997664 hasConceptScore W2344997664C21951064 @default.
- W2344997664 hasConceptScore W2344997664C2775944816 @default.
- W2344997664 hasConceptScore W2344997664C486523 @default.
- W2344997664 hasConceptScore W2344997664C61156836 @default.
- W2344997664 hasConceptScore W2344997664C71240020 @default.
- W2344997664 hasFunder F4320337354 @default.
- W2344997664 hasFunder F4320337355 @default.
- W2344997664 hasIssue "10" @default.
- W2344997664 hasLocation W23449976641 @default.
- W2344997664 hasLocation W23449976642 @default.
- W2344997664 hasLocation W23449976643 @default.
- W2344997664 hasLocation W23449976644 @default.
- W2344997664 hasOpenAccess W2344997664 @default.
- W2344997664 hasPrimaryLocation W23449976641 @default.
- W2344997664 hasRelatedWork W2022650884 @default.
- W2344997664 hasRelatedWork W2041713437 @default.
- W2344997664 hasRelatedWork W2044558520 @default.
- W2344997664 hasRelatedWork W2085314440 @default.
- W2344997664 hasRelatedWork W2356956102 @default.
- W2344997664 hasRelatedWork W2802059383 @default.
- W2344997664 hasRelatedWork W2949629622 @default.
- W2344997664 hasRelatedWork W2949853668 @default.
- W2344997664 hasRelatedWork W2952284392 @default.
- W2344997664 hasRelatedWork W2952891741 @default.
- W2344997664 hasVolume "81" @default.
- W2344997664 isParatext "false" @default.
- W2344997664 isRetracted "false" @default.
- W2344997664 magId "2344997664" @default.
- W2344997664 workType "article" @default.