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- W2345029182 abstract "Objective To investigate the effects of grape seed extract procyanidin(PA) on proliferation and apoptosisof human hepatoma cell line SMMC-7721.Methods Human hepatoma cell line SMMC-7721 of logarithm vegetal period,were cultured with different density of PA(20,40,60 mg/L) for 24 hours,the suppression rate of cell proliferation wasmeasured by MTT assay,and apoptosis was detected by flow cytometry.Cells in each group were investigated with MDA,SOD,ROS respectively.Results The suppression rate of cell proliferation were(22.7±1.8)%,(38.6±1.9)% and(47.6±2.5)%,respectively,while the apoptotic rate was(19.69±5.1)%,(29.7±2.9)% and(48.5±4.5)%.Both the suppression rate and the apoptotic rate elevated with the increasing PAconcerntration(P0.05).Contrast to con-trol group,the procyanidins with every doses could reduce MDA,ROS contents(P0.05) and increase SOD levels(P0.05).Conclusions PA could inhibit the growth of SMMC-7721 cells and induce apoptosis in vitro in a concentration-de-pendent manner.The mechanism could possibly contribute to reduce MDA,ROS contents,and increase SOD levels." @default.
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- W2345029182 date "2010-01-01" @default.
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- W2345029182 title "Effects of procyanidin on proliferation and apoptosis of human hepatoma cell line SMMC-7721" @default.
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