FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345058332> ?p ?o ?g. }

• W2345058332 endingPage "1575" @default.
• W2345058332 startingPage "1567" @default.
• W2345058332 abstract "The adhesion of monocytes to human umbilical vein endothelial cells (HUVECs) plays a crucial role in the initiation of atherosclerosis. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are two important molecules involved in the adhesion of monocytes to HUVECs. Previous studies have suggested that artemisinin, apart from an anti-malarial agent, also has other effects. In the present study, we found that artemisinin significantly decreased the adhesion of monocytes to tumor necrosis factor-α (TNF-α)-stimulated HUVECs in a dose-dependent manner and suppressed the mRNA and protein level of ICAM-1 and VCAM-1 in the TNF-α-stimulated HUVECs. In addition, the nuclear factor-κB (NF-κB) inhibitor, Bay 11-7082, and mitogen-activated protein kinase (MAPK) inhibitors (SB203580 and U0126) respectively reduced the adhesion of monocytes to TNF-α-stimulated HUVECs, and suppressed ICAM-1 and VCAM-1 expression in TNF-α stimulated HUVECs. Moreover, artemisinin impeded the activation of the NF-κB and MAPK signaling pathways. Furthermore, Bay 11-7082 significantly decreased the phosphorylation of levels extracellular signal-regulated protein kinase (ERK)1/2, p38 and c-Jun N-terminal kinase (JNK). Taken together, the findings of our study indicated that artemisinin blocked monocyte adhesion to TNF-α-stimulated to HUVECs by downregulating ICAM-1 and VCAM-1 expression in the TNF-α-stimulated HUVECs. Artemisinin may thus have potential for use in the protection against the early development of atherosclerotic lesions." @default.
• W2345058332 created "2016-06-24" @default.
• W2345058332 creator A5011320454 @default.
• W2345058332 creator A5023597320 @default.
• W2345058332 creator A5033632697 @default.
• W2345058332 creator A5038986923 @default.
• W2345058332 creator A5040878398 @default.
• W2345058332 creator A5053809001 @default.
• W2345058332 creator A5054758414 @default.
• W2345058332 creator A5054811966 @default.
• W2345058332 date "2016-04-26" @default.
• W2345058332 modified "2023-09-23" @default.
• W2345058332 title "Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro" @default.
• W2345058332 cites W1541159720 @default.
• W2345058332 cites W1552829599 @default.
• W2345058332 cites W1921371649 @default.
• W2345058332 cites W1980038357 @default.
• W2345058332 cites W1991783074 @default.
• W2345058332 cites W1997454000 @default.
• W2345058332 cites W2017631641 @default.
• W2345058332 cites W2018480833 @default.
• W2345058332 cites W2018893673 @default.
• W2345058332 cites W2029335415 @default.
• W2345058332 cites W2031370124 @default.
• W2345058332 cites W2032955209 @default.
• W2345058332 cites W2040585929 @default.
• W2345058332 cites W2052435822 @default.
• W2345058332 cites W2054805566 @default.
• W2345058332 cites W2057737390 @default.
• W2345058332 cites W2062051365 @default.
• W2345058332 cites W2066724090 @default.
• W2345058332 cites W2072703437 @default.
• W2345058332 cites W2073882423 @default.
• W2345058332 cites W2077452278 @default.
• W2345058332 cites W2083403064 @default.
• W2345058332 cites W2083974519 @default.
• W2345058332 cites W2091892148 @default.
• W2345058332 cites W2094941678 @default.
• W2345058332 cites W2106219216 @default.
• W2345058332 cites W2120058838 @default.
• W2345058332 cites W2126039851 @default.
• W2345058332 cites W2129265683 @default.
• W2345058332 cites W2139319526 @default.
• W2345058332 cites W2152378595 @default.
• W2345058332 cites W2156593520 @default.
• W2345058332 cites W2165056204 @default.
• W2345058332 cites W2331176038 @default.
• W2345058332 cites W4254041232 @default.
• W2345058332 doi "https://doi.org/10.3892/ijmm.2016.2579" @default.
• W2345058332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4866958" @default.
• W2345058332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27122190" @default.
• W2345058332 hasPublicationYear "2016" @default.
• W2345058332 type Work @default.
• W2345058332 sameAs 2345058332 @default.
• W2345058332 citedByCount "33" @default.
• W2345058332 countsByYear W23450583322017 @default.
• W2345058332 countsByYear W23450583322018 @default.
• W2345058332 countsByYear W23450583322019 @default.
• W2345058332 countsByYear W23450583322020 @default.
• W2345058332 countsByYear W23450583322021 @default.
• W2345058332 countsByYear W23450583322022 @default.
• W2345058332 countsByYear W23450583322023 @default.
• W2345058332 crossrefType "journal-article" @default.
• W2345058332 hasAuthorship W2345058332A5011320454 @default.
• W2345058332 hasAuthorship W2345058332A5023597320 @default.
• W2345058332 hasAuthorship W2345058332A5033632697 @default.
• W2345058332 hasAuthorship W2345058332A5038986923 @default.
• W2345058332 hasAuthorship W2345058332A5040878398 @default.
• W2345058332 hasAuthorship W2345058332A5053809001 @default.
• W2345058332 hasAuthorship W2345058332A5054758414 @default.
• W2345058332 hasAuthorship W2345058332A5054811966 @default.
• W2345058332 hasBestOaLocation W23450583321 @default.
• W2345058332 hasConcept C1491633281 @default.
• W2345058332 hasConcept C16224149 @default.
• W2345058332 hasConcept C17991360 @default.
• W2345058332 hasConcept C184235292 @default.
• W2345058332 hasConcept C185592680 @default.
• W2345058332 hasConcept C185946421 @default.
• W2345058332 hasConcept C202751555 @default.
• W2345058332 hasConcept C203014093 @default.
• W2345058332 hasConcept C2776120307 @default.
• W2345058332 hasConcept C2777411675 @default.
• W2345058332 hasConcept C2778048844 @default.
• W2345058332 hasConcept C2778371730 @default.
• W2345058332 hasConcept C2781184567 @default.
• W2345058332 hasConcept C2909375385 @default.
• W2345058332 hasConcept C51551487 @default.
• W2345058332 hasConcept C55493867 @default.
• W2345058332 hasConcept C57074206 @default.
• W2345058332 hasConcept C62478195 @default.
• W2345058332 hasConcept C85789140 @default.
• W2345058332 hasConcept C86803240 @default.
• W2345058332 hasConcept C95444343 @default.
• W2345058332 hasConcept C97029542 @default.
• W2345058332 hasConceptScore W2345058332C1491633281 @default.
• W2345058332 hasConceptScore W2345058332C16224149 @default.
• W2345058332 hasConceptScore W2345058332C17991360 @default.
• W2345058332 hasConceptScore W2345058332C184235292 @default.

• next