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- W2345200264 endingPage "6304" @default.
- W2345200264 startingPage "6267" @default.
- W2345200264 abstract "The last five years have witnessed major developments in the understanding of the allosteric phenomenon, broadly defined as coupling between remote molecular sites. Such advances have been driven not only by new theoretical models and pharmacological applications of allostery, but also by progress in the experimental approaches designed to map allosteric sites and transitions. Among these techniques, NMR spectroscopy has played a major role given its unique near-atomic resolution and sensitivity to the dynamics that underlie allosteric couplings. Here, we highlight recent progress in the NMR methods tailored to investigate allostery with the goal of offering an overview of which NMR approaches are best suited for which allosterically relevant questions. The picture of the allosteric NMR toolbox is provided starting from one of the simplest models of allostery (i.e., the four-state thermodynamic cycle) and continuing to more complex multistate mechanisms. We also review how such an NMR toolbox has assisted the elucidation of the allosteric molecular basis for disease-related mutations and the discovery of novel leads for allosteric drugs. From this overview, it is clear that NMR plays a central role not only in experimentally validating transformative theories of allostery, but also in tapping the full translational potential of allosteric systems." @default.
- W2345200264 created "2016-06-24" @default.
- W2345200264 creator A5011010472 @default.
- W2345200264 creator A5024735414 @default.
- W2345200264 date "2016-04-25" @default.
- W2345200264 modified "2023-09-29" @default.
- W2345200264 title "Advances in NMR Methods To Map Allosteric Sites: From Models to Translation" @default.
- W2345200264 cites W1080346916 @default.
- W2345200264 cites W1438791329 @default.
- W2345200264 cites W1445327633 @default.
- W2345200264 cites W1483278983 @default.
- W2345200264 cites W1489827117 @default.
- W2345200264 cites W1489910389 @default.
- W2345200264 cites W1507878352 @default.
- W2345200264 cites W1520350430 @default.
- W2345200264 cites W1523733498 @default.
- W2345200264 cites W1524300055 @default.
- W2345200264 cites W1541103167 @default.
- W2345200264 cites W1565629324 @default.
- W2345200264 cites W1566779496 @default.
- W2345200264 cites W1571794098 @default.
- W2345200264 cites W1643393773 @default.
- W2345200264 cites W1701270066 @default.
- W2345200264 cites W1810581179 @default.
- W2345200264 cites W1857393839 @default.
- W2345200264 cites W1861552875 @default.
- W2345200264 cites W1890431460 @default.
- W2345200264 cites W1895286762 @default.
- W2345200264 cites W1900212418 @default.
- W2345200264 cites W190397328 @default.
- W2345200264 cites W1921118755 @default.
- W2345200264 cites W1940272364 @default.
- W2345200264 cites W1950122733 @default.
- W2345200264 cites W1963588433 @default.
- W2345200264 cites W1964439982 @default.
- W2345200264 cites W1964840468 @default.
- W2345200264 cites W1965076207 @default.
- W2345200264 cites W1966496513 @default.
- W2345200264 cites W1966693725 @default.
- W2345200264 cites W1966995592 @default.
- W2345200264 cites W1967182435 @default.
- W2345200264 cites W1968824596 @default.
- W2345200264 cites W1970376071 @default.
- W2345200264 cites W1970573724 @default.
- W2345200264 cites W1971188486 @default.
- W2345200264 cites W1972122806 @default.
- W2345200264 cites W1972660398 @default.
- W2345200264 cites W1974207257 @default.
- W2345200264 cites W1974326515 @default.
- W2345200264 cites W1974709395 @default.
- W2345200264 cites W1974956783 @default.
- W2345200264 cites W1975757940 @default.
- W2345200264 cites W1976569870 @default.
- W2345200264 cites W1978545297 @default.
- W2345200264 cites W1979199493 @default.
- W2345200264 cites W1979699273 @default.
- W2345200264 cites W1979785415 @default.
- W2345200264 cites W1981063141 @default.
- W2345200264 cites W1981086730 @default.
- W2345200264 cites W1981159786 @default.
- W2345200264 cites W1981978621 @default.
- W2345200264 cites W1982004004 @default.
- W2345200264 cites W1982018428 @default.
- W2345200264 cites W1982615479 @default.
- W2345200264 cites W1982798915 @default.
- W2345200264 cites W1982800257 @default.
- W2345200264 cites W1982978449 @default.
- W2345200264 cites W1983040213 @default.
- W2345200264 cites W1983165588 @default.
- W2345200264 cites W1983869311 @default.
- W2345200264 cites W1984450635 @default.
- W2345200264 cites W1986301309 @default.
- W2345200264 cites W1986304086 @default.
- W2345200264 cites W1986541704 @default.
- W2345200264 cites W1987889857 @default.
- W2345200264 cites W1987910120 @default.
- W2345200264 cites W1987982273 @default.
- W2345200264 cites W1988299757 @default.
- W2345200264 cites W1988610650 @default.
- W2345200264 cites W1988913922 @default.
- W2345200264 cites W1989044022 @default.
- W2345200264 cites W1990472520 @default.
- W2345200264 cites W1991887913 @default.
- W2345200264 cites W1992838223 @default.
- W2345200264 cites W1993660866 @default.
- W2345200264 cites W1994713811 @default.
- W2345200264 cites W1996859443 @default.
- W2345200264 cites W1997016617 @default.
- W2345200264 cites W1997179133 @default.
- W2345200264 cites W1997291282 @default.
- W2345200264 cites W1997596850 @default.
- W2345200264 cites W1997993828 @default.
- W2345200264 cites W1998093640 @default.
- W2345200264 cites W1998213944 @default.
- W2345200264 cites W1999268424 @default.
- W2345200264 cites W1999350919 @default.
- W2345200264 cites W2000681369 @default.
- W2345200264 cites W2001469425 @default.