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• W2345349969 abstract "Problem Association between PAI ‐1 4G/5G polymorphism and reproductive failures has been postulated. We aimed to investigate its impact on metabolic, hormonal, and immune profiles of women with reproductive failures. Method of study A retrospective study was carried out in 208 women with a history of reproductive failure. Study patients were divided into three groups: women with repeated implantation failure ( RIF , n = 40), recurrent pregnancy loss ( RPL , n = 113), and both RIF and RPL ( n = 55). Fertile controls were 92. Results PAI ‐1 4G/4G was prevalent in RPL , RIF , and RIF / RPL groups when compared with controls ( P = 0 .003) and associated with increased risks of RIF , RPL , and RIF with RPL ( OR = 4.5, 2.2 and 2.7). Women with PAI ‐1 4G/4G have significantly higher BMI , glucose, and PAI ‐1 levels and lower NK cytotoxicity when compared with women without PAI ‐1 4G/4G. Conclusion PAI ‐1 4G/5G polymorphism plays a major role in the pathogenesis of RPL and RIF by altering metabolic and immunological profiles." @default.
• W2345349969 created "2016-06-24" @default.
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• W2345349969 date "2016-05-04" @default.
• W2345349969 modified "2023-10-05" @default.
• W2345349969 title "Plasminogen Activator Inhibitor-1 4G/5G Polymorphism is Associated with Reproductive Failure: Metabolic, Hormonal, and Immune Profiles" @default.
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• W2345349969 doi "https://doi.org/10.1111/aji.12516" @default.
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