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• W2345416096 abstract "Physicians often administer corticosteroids for the treatment of fluid and vasoactive infusion dependent pediatric shock. This use of corticosteroids is controversial, however, and has never been studied in a pediatric randomized controlled trial (RCT). This pilot trial will determine the feasibility of a larger RCT on the role of corticosteroids in pediatric shock. Steroids in Fluid and/or Vasoactive Infusion Dependent Pediatric Shock (STRIPES) is a pragmatic, seven-center, double-blind, pilot RCT. We aim to randomize 72 pediatric patients with fluid and vasoactive infusion dependent shock to receive either hydrocortisone or a saline placebo for 7 days or until clinical stability, whichever occurs first. The primary outcome of this pilot trial is the feasibility of recruitment, defined as the number of patients enrolled over a 1-year period. Secondary outcomes include the frequency of, and reasons for, open-label steroid use, protocol adherence, incidence of mortality and corticosteroid-associated adverse events, time to discontinuation of inotropes, and feasibility of blood sampling. Corticosteroids are used for the treatment of pediatric shock without sufficient evidence to support this practice. While there is a scientific rationale and limited data supporting their use in this setting, there is also evidence from other populations suggesting potential harm. The STRIPES pilot study will assess the feasibility of a larger, much needed trial powered for clinically important outcomes. ClinicalTrials.gov: NCT02044159" @default.
• W2345416096 created "2016-06-24" @default.
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• W2345416096 date "2016-05-06" @default.
• W2345416096 modified "2023-09-27" @default.
• W2345416096 title "Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial" @default.
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• W2345416096 doi "https://doi.org/10.1186/s13063-016-1365-6" @default.
• W2345416096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4859989" @default.
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