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- W2345507226 abstract "Subjective responses to psychostimulants vary, the basis of which is poorly understood, especially in relation to possible cortical contributions. Here, we tested for relationships between participants' positive subjective responses to oral d-amphetamine (dAMPH) versus placebo and variability in striatal and extrastriatal dopamine (DA) receptor availability and release, measured via positron emission tomography (PET) with the radiotracer (18)F-fallypride. Analyses focused on 35 healthy adult participants showing positive subjective effects to dAMPH measured via the Drug Effects Questionnaire (DEQ) Feel, Like, High, and Want More subscales (Responders), and were repeated after inclusion of 11 subjects who lacked subjective responses. Associations between peak DEQ subscale ratings and both baseline (18)F-fallypride binding potential (BPnd; an index of D2/D3 receptor availability) and the percentage change in BPnd post dAMPH (%ΔBPnd; a measure of DA release) were assessed. Baseline BPnd in ventromedial prefrontal cortex (vmPFC) predicted the peak level of High reported following dAMPH. Furthermore, %ΔBPnd in vmPFC positively correlated with DEQ Want More ratings. DEQ Want More was also positively correlated with %ΔBPnd in right ventral striatum and left insula. This work indicates that characteristics of DA functioning in vmPFC, a cortical area implicated in subjective valuation, are associated with both subjective high and incentive (wanting) responses. The observation that insula %ΔBPnd was associated with drug wanting converges with evidence suggesting its role in drug craving. These findings highlight the importance of variability in DA signaling in specific paralimbic cortical regions in dAMPH's subjective response, which may confer risk for abusing psychostimulants." @default.
- W2345507226 created "2016-06-24" @default.
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- W2345507226 date "2016-09-01" @default.
- W2345507226 modified "2023-10-16" @default.
- W2345507226 title "Variability in paralimbic dopamine signaling correlates with subjective responses to d-amphetamine" @default.
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- W2345507226 cites W1964511631 @default.
- W2345507226 cites W1965232467 @default.
- W2345507226 cites W1966114780 @default.
- W2345507226 cites W1970211188 @default.
- W2345507226 cites W1976397511 @default.
- W2345507226 cites W1978453350 @default.
- W2345507226 cites W1982127977 @default.
- W2345507226 cites W1983332126 @default.
- W2345507226 cites W1985623917 @default.
- W2345507226 cites W1986691597 @default.
- W2345507226 cites W1992615559 @default.
- W2345507226 cites W1994925343 @default.
- W2345507226 cites W1997829966 @default.
- W2345507226 cites W2006096283 @default.
- W2345507226 cites W2017673513 @default.
- W2345507226 cites W2018566725 @default.
- W2345507226 cites W2024038317 @default.
- W2345507226 cites W2031702196 @default.
- W2345507226 cites W2032714267 @default.
- W2345507226 cites W2037973113 @default.
- W2345507226 cites W2038018468 @default.
- W2345507226 cites W2043250383 @default.
- W2345507226 cites W2044810175 @default.
- W2345507226 cites W2050019172 @default.
- W2345507226 cites W2062877668 @default.
- W2345507226 cites W2068715462 @default.
- W2345507226 cites W2071825212 @default.
- W2345507226 cites W2072799373 @default.
- W2345507226 cites W2074624810 @default.
- W2345507226 cites W2079331765 @default.
- W2345507226 cites W2079598508 @default.
- W2345507226 cites W2085954289 @default.
- W2345507226 cites W2088522292 @default.
- W2345507226 cites W2105109101 @default.
- W2345507226 cites W2105909330 @default.
- W2345507226 cites W2106676291 @default.
- W2345507226 cites W2106862702 @default.
- W2345507226 cites W2111464173 @default.
- W2345507226 cites W2113737964 @default.
- W2345507226 cites W2114277272 @default.
- W2345507226 cites W2116649573 @default.
- W2345507226 cites W2117671988 @default.
- W2345507226 cites W2122284725 @default.
- W2345507226 cites W2123132629 @default.
- W2345507226 cites W2125364966 @default.
- W2345507226 cites W2127798782 @default.
- W2345507226 cites W2128472904 @default.
- W2345507226 cites W2138718114 @default.
- W2345507226 cites W2142166658 @default.
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- W2345507226 cites W2147639837 @default.
- W2345507226 cites W2150944548 @default.
- W2345507226 cites W2162366325 @default.
- W2345507226 cites W2162421322 @default.
- W2345507226 cites W2163805252 @default.
- W2345507226 cites W2163989393 @default.
- W2345507226 cites W2164282817 @default.
- W2345507226 cites W2166279933 @default.
- W2345507226 cites W2166830183 @default.
- W2345507226 cites W2168733129 @default.
- W2345507226 cites W2169839077 @default.
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- W2345507226 doi "https://doi.org/10.1016/j.neuropharm.2016.05.004" @default.
- W2345507226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4912942" @default.
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