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• W2345522085 abstract "Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (anti-PD1-antibody) and ipilimumab (anti-CTLA-4 antibody) who developed systemic rash along with severe acute tubulointerstitial nephritis after two doses of combination therapy. Kidney biopsy and peripheral blood immune profile revealed highly proliferative and cytotoxic T cell features. Herein, we discuss the pathophysiology and management of immune checkpoint blockade-related adverse events." @default.
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• W2345522085 date "2016-05-04" @default.
• W2345522085 modified "2023-10-17" @default.
• W2345522085 title "Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma" @default.
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• W2345522085 doi "https://doi.org/10.1093/ckj/sfw024" @default.
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