FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345615963> ?p ?o ?g. }

• W2345615963 abstract "Traditional Chinese medicine (TCM) has been used to treat tumors for years and has been demonstrated to be effective. However, the underlying molecular mechanisms of herbs remain unclear. This study aims to ascertain molecular targets of herbs prolonging survival time of patients with advanced hepatocellular carcinoma (HCC) based on network pharmacology, and to establish a research method for accurate treatment of TCM. The survival benefit of TCM treatment with Chinese herbal medicine (CHM) was proved by Kaplan-Meier method and Cox regression analysis among 288 patients. The correlation between herbs and survival time was performed by bivariate correlation analysis. Network pharmacology method was utilized to construct the active ingredient-target networks of herbs that were responsible for the beneficial effects against HCC. Cox regression analysis showed CHM was an independent favorable prognostic factor. The median survival time was 13 months and the 5-year overall survival rates were 2.61% in the TCM group, while there were 6 months, 0 in the non-TCM group. Correlation analysis demonstrated that 8 herbs closely associated with prognosis. Network pharmacology analysis revealed that the 8 herbs regulated multiple HCC relative genes, among which the genes affected proliferation (KRAS, AKT2, MAPK), metastasis (SRC, MMP), angiogenesis (PTGS2) and apoptosis (CASP3) etc." @default.
• W2345615963 created "2016-06-24" @default.
• W2345615963 creator A5005573647 @default.
• W2345615963 creator A5026464895 @default.
• W2345615963 creator A5035290735 @default.
• W2345615963 creator A5040205022 @default.
• W2345615963 creator A5045391521 @default.
• W2345615963 creator A5049410725 @default.
• W2345615963 creator A5051795250 @default.
• W2345615963 creator A5057273967 @default.
• W2345615963 creator A5058225466 @default.
• W2345615963 creator A5068805735 @default.
• W2345615963 creator A5078465675 @default.
• W2345615963 date "2016-05-01" @default.
• W2345615963 modified "2023-10-15" @default.
• W2345615963 title "Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology" @default.
• W2345615963 cites W1592483428 @default.
• W2345615963 cites W1728384300 @default.
• W2345615963 cites W1937615875 @default.
• W2345615963 cites W1970263201 @default.
• W2345615963 cites W1972150275 @default.
• W2345615963 cites W1974083074 @default.
• W2345615963 cites W1977118413 @default.
• W2345615963 cites W1980572680 @default.
• W2345615963 cites W1984621921 @default.
• W2345615963 cites W1993352447 @default.
• W2345615963 cites W1997857177 @default.
• W2345615963 cites W1998790582 @default.
• W2345615963 cites W1998897129 @default.
• W2345615963 cites W2002447800 @default.
• W2345615963 cites W2008080348 @default.
• W2345615963 cites W2008676682 @default.
• W2345615963 cites W2015801294 @default.
• W2345615963 cites W2016111230 @default.
• W2345615963 cites W2032649044 @default.
• W2345615963 cites W2033591223 @default.
• W2345615963 cites W2050113624 @default.
• W2345615963 cites W2050543082 @default.
• W2345615963 cites W2061136308 @default.
• W2345615963 cites W2061743943 @default.
• W2345615963 cites W2067754836 @default.
• W2345615963 cites W2071524470 @default.
• W2345615963 cites W2088886967 @default.
• W2345615963 cites W2091525053 @default.
• W2345615963 cites W2094624294 @default.
• W2345615963 cites W2100647531 @default.
• W2345615963 cites W2103351853 @default.
• W2345615963 cites W2111413196 @default.
• W2345615963 cites W2112513984 @default.
• W2345615963 cites W2121307471 @default.
• W2345615963 cites W2121707384 @default.
• W2345615963 cites W2124679671 @default.
• W2345615963 cites W2132932211 @default.
• W2345615963 cites W2138180968 @default.
• W2345615963 cites W2149818581 @default.
• W2345615963 cites W2155142785 @default.
• W2345615963 cites W2162732628 @default.
• W2345615963 cites W2165211007 @default.
• W2345615963 cites W2169961966 @default.
• W2345615963 cites W2170552969 @default.
• W2345615963 cites W2170719700 @default.
• W2345615963 cites W2171541660 @default.
• W2345615963 cites W2219978888 @default.
• W2345615963 cites W2324986020 @default.
• W2345615963 cites W2915720971 @default.
• W2345615963 cites W794689245 @default.
• W2345615963 cites W978308701 @default.
• W2345615963 doi "https://doi.org/10.1038/srep24944" @default.
• W2345615963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4855233" @default.
• W2345615963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27143508" @default.
• W2345615963 hasPublicationYear "2016" @default.
• W2345615963 type Work @default.
• W2345615963 sameAs 2345615963 @default.
• W2345615963 citedByCount "69" @default.
• W2345615963 countsByYear W23456159632016 @default.
• W2345615963 countsByYear W23456159632017 @default.
• W2345615963 countsByYear W23456159632018 @default.
• W2345615963 countsByYear W23456159632019 @default.
• W2345615963 countsByYear W23456159632020 @default.
• W2345615963 countsByYear W23456159632021 @default.
• W2345615963 countsByYear W23456159632022 @default.
• W2345615963 countsByYear W23456159632023 @default.
• W2345615963 crossrefType "journal-article" @default.
• W2345615963 hasAuthorship W2345615963A5005573647 @default.
• W2345615963 hasAuthorship W2345615963A5026464895 @default.
• W2345615963 hasAuthorship W2345615963A5035290735 @default.
• W2345615963 hasAuthorship W2345615963A5040205022 @default.
• W2345615963 hasAuthorship W2345615963A5045391521 @default.
• W2345615963 hasAuthorship W2345615963A5049410725 @default.
• W2345615963 hasAuthorship W2345615963A5051795250 @default.
• W2345615963 hasAuthorship W2345615963A5057273967 @default.
• W2345615963 hasAuthorship W2345615963A5058225466 @default.
• W2345615963 hasAuthorship W2345615963A5068805735 @default.
• W2345615963 hasAuthorship W2345615963A5078465675 @default.
• W2345615963 hasBestOaLocation W23456159631 @default.
• W2345615963 hasConcept C10515644 @default.
• W2345615963 hasConcept C117220453 @default.
• W2345615963 hasConcept C121608353 @default.
• W2345615963 hasConcept C126322002 @default.
• W2345615963 hasConcept C142724271 @default.

• next