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• W2345647522 abstract "Article history: Received on: 09/01/2016 Revised on: 10/02/2016 Accepted on: 17/03/2016 Available online: 30/04/2016 The objective of the present study was to improve the physicochemical properties of poorly water soluble cefixime by preparing its nanoparticles using a hydrophilic polymer polyvinylpyrrolidone K30 (PVP). The nanoparticles of cefixime were prepared by spray drying technique. A 3 2 factorial design approach was employed for the optimization of nanoparticle batches. The present model demonstrated significance of factors such as drug to polymer ratio (X1) and feed flow rate (X2) of spray dryer on the production yield (Y1), particle size (Y2) and % drug release at 15 min (Y3). The pure drug and prepared nanoparticles were characterized by Fourier transformation infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray powder diffraction (XPRD), Scanning electron microscopy (SEM), particle size, saturation solubility and in vitro drug release. The results of DSC and XPRD revealed transformation of the crystalline nature of cefixime into an amorphous form which was supported by SEM. A significant improvement in solubility and dissolution rate was noticed in case of prepared nanoparticles as compared to pure cefixime. These results suggested that preparation of polymeric nanoparticles by spray drying technique might be a promising approach for improving the physicochemical properties of cefixime." @default.
• W2345647522 created "2016-06-24" @default.
• W2345647522 creator A5014775839 @default.
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• W2345647522 date "2016-01-01" @default.
• W2345647522 modified "2023-10-05" @default.
• W2345647522 title "Physicochemical characterization of spray dried cefixime polymeric nanoparticles using factorial design approach" @default.
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• W2345647522 doi "https://doi.org/10.7324/japs.2016.60417" @default.
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