Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345725858> ?p ?o ?g. }
- W2345725858 endingPage "4175" @default.
- W2345725858 startingPage "4170" @default.
- W2345725858 abstract "Acetamido derivatives of the naturally antibacterial non-β-lactam lactivicin (LTV) have improved activity against their penicillin binding protein targets and reduced hydrolysis by β-lactamases, but penetration into Gram-negative bacteria is still relatively poor. Here we report that modification of the LTV lactone with a catechol-type siderophore increases potency 1,000-fold against Stenotrophomonas maltophilia, a species renowned for its insusceptibility to antimicrobials. The MIC90 of modified lactone compound 17 (LTV17) against a global collection of extensively drug-resistant clinical S. maltophilia isolates was 0.063 μg · ml(-1) Sideromimic modification does not reduce the ability of LTVs to induce production of the L1 and L2 β-lactamases in S. maltophilia and does not reduce the rate at which LTVs are hydrolyzed by L1 or L2. We conclude, therefore, that lactivicin modification with a siderophore known to be preferentially used by S. maltophilia substantially increases penetration via siderophore uptake. LTV17 has the potential to be developed as a novel antimicrobial for treatment of infections by S. maltophilia More generally, our work shows that sideromimic modification in a species-targeted manner might prove useful for the development of narrow-spectrum antimicrobials that have reduced collateral effects." @default.
- W2345725858 created "2016-06-24" @default.
- W2345725858 creator A5004688249 @default.
- W2345725858 creator A5026623535 @default.
- W2345725858 creator A5037611984 @default.
- W2345725858 creator A5042398293 @default.
- W2345725858 creator A5060563064 @default.
- W2345725858 creator A5068535935 @default.
- W2345725858 creator A5077757990 @default.
- W2345725858 creator A5079274078 @default.
- W2345725858 date "2016-07-01" @default.
- W2345725858 modified "2023-09-30" @default.
- W2345725858 title "Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates" @default.
- W2345725858 cites W1820263039 @default.
- W2345725858 cites W1905789354 @default.
- W2345725858 cites W1968014038 @default.
- W2345725858 cites W1982669838 @default.
- W2345725858 cites W1985561651 @default.
- W2345725858 cites W1995987590 @default.
- W2345725858 cites W1996937282 @default.
- W2345725858 cites W2001220233 @default.
- W2345725858 cites W2009359065 @default.
- W2345725858 cites W2038730767 @default.
- W2345725858 cites W2043338527 @default.
- W2345725858 cites W2046855998 @default.
- W2345725858 cites W2066067348 @default.
- W2345725858 cites W2076141045 @default.
- W2345725858 cites W2099675207 @default.
- W2345725858 cites W2103490150 @default.
- W2345725858 cites W2103747393 @default.
- W2345725858 cites W2110978306 @default.
- W2345725858 cites W2114720004 @default.
- W2345725858 cites W2126676410 @default.
- W2345725858 cites W2142908746 @default.
- W2345725858 cites W2149103203 @default.
- W2345725858 cites W2155317724 @default.
- W2345725858 cites W2159643438 @default.
- W2345725858 cites W2162578848 @default.
- W2345725858 cites W2163206615 @default.
- W2345725858 cites W2164748154 @default.
- W2345725858 cites W2165765825 @default.
- W2345725858 cites W2316995090 @default.
- W2345725858 cites W2318729852 @default.
- W2345725858 doi "https://doi.org/10.1128/aac.00371-16" @default.
- W2345725858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4914698" @default.
- W2345725858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27139464" @default.
- W2345725858 hasPublicationYear "2016" @default.
- W2345725858 type Work @default.
- W2345725858 sameAs 2345725858 @default.
- W2345725858 citedByCount "14" @default.
- W2345725858 countsByYear W23457258582017 @default.
- W2345725858 countsByYear W23457258582018 @default.
- W2345725858 countsByYear W23457258582019 @default.
- W2345725858 countsByYear W23457258582021 @default.
- W2345725858 countsByYear W23457258582022 @default.
- W2345725858 countsByYear W23457258582023 @default.
- W2345725858 crossrefType "journal-article" @default.
- W2345725858 hasAuthorship W2345725858A5004688249 @default.
- W2345725858 hasAuthorship W2345725858A5026623535 @default.
- W2345725858 hasAuthorship W2345725858A5037611984 @default.
- W2345725858 hasAuthorship W2345725858A5042398293 @default.
- W2345725858 hasAuthorship W2345725858A5060563064 @default.
- W2345725858 hasAuthorship W2345725858A5068535935 @default.
- W2345725858 hasAuthorship W2345725858A5077757990 @default.
- W2345725858 hasAuthorship W2345725858A5079274078 @default.
- W2345725858 hasBestOaLocation W23457258581 @default.
- W2345725858 hasConcept C108319773 @default.
- W2345725858 hasConcept C185592680 @default.
- W2345725858 hasConcept C202751555 @default.
- W2345725858 hasConcept C2776352461 @default.
- W2345725858 hasConcept C2777637488 @default.
- W2345725858 hasConcept C4937899 @default.
- W2345725858 hasConcept C523546767 @default.
- W2345725858 hasConcept C54355233 @default.
- W2345725858 hasConcept C55493867 @default.
- W2345725858 hasConcept C57992300 @default.
- W2345725858 hasConcept C86803240 @default.
- W2345725858 hasConcept C89423630 @default.
- W2345725858 hasConceptScore W2345725858C108319773 @default.
- W2345725858 hasConceptScore W2345725858C185592680 @default.
- W2345725858 hasConceptScore W2345725858C202751555 @default.
- W2345725858 hasConceptScore W2345725858C2776352461 @default.
- W2345725858 hasConceptScore W2345725858C2777637488 @default.
- W2345725858 hasConceptScore W2345725858C4937899 @default.
- W2345725858 hasConceptScore W2345725858C523546767 @default.
- W2345725858 hasConceptScore W2345725858C54355233 @default.
- W2345725858 hasConceptScore W2345725858C55493867 @default.
- W2345725858 hasConceptScore W2345725858C57992300 @default.
- W2345725858 hasConceptScore W2345725858C86803240 @default.
- W2345725858 hasConceptScore W2345725858C89423630 @default.
- W2345725858 hasFunder F4320334626 @default.
- W2345725858 hasFunder F4320334627 @default.
- W2345725858 hasIssue "7" @default.
- W2345725858 hasLocation W23457258581 @default.
- W2345725858 hasLocation W23457258582 @default.
- W2345725858 hasLocation W23457258583 @default.
- W2345725858 hasLocation W23457258584 @default.
- W2345725858 hasLocation W23457258585 @default.