FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345731394> ?p ?o ?g. }

• W2345731394 endingPage "318" @default.
• W2345731394 startingPage "313" @default.
• W2345731394 abstract "Inhibitor of DNA binding (Id)3 is a member of the Id multigene family of dominant‑negative helix‑loop-helix transcription factors, which function as oncogenes or tumor suppressors in human cancers. Its upregulation was recently shown to have inhibitory effects on lung cancer, which is the leading cause of cancer‑associated mortality worldwide. As drug resistance represents a major bottleneck of cancer therapy, the present study assessed the ability of Id3 to inhibit cisplatin‑resistant A549 lung adenocarcinoma cells (A549/DDP). A549/DPP cells were transiently transfected with enhanced green fluorescence protein overexpression plasmid (pEGFP) or Id3 overexpression plasmid (Id3/pEGFP), which was confirmed by confocal fluorescence microscopy, PCR and western blot analysis. The effects of Id3 on the viability and apoptosis of A549/DDP were determined using an MTT assay, fluorescence microscopy with Hoechst 33258 staining and flow cytometry following Annexin V/propidium iodide double staining. The results revealed that overexpression of Id3 significantly inhibited the proliferation and viability of A549/DDP cells in a time‑dependent manner. Furthermore, overexpression of Id3 significantly increased the apoptotic rate of A549/DDP cells from 2.73 to 16.92%, confirming the implication of Id3 in the negative control of tumour growth. The results of the present study revealed that overexpression of Id3 may serve as a novel strategy for inhibiting cisplatin‑sensitive lung cancer. Further experiments will be performed to determine whether Id3 overexpression could enhance the sensitivity of lung cancer cells to DDP." @default.
• W2345731394 created "2016-06-24" @default.
• W2345731394 creator A5011046893 @default.
• W2345731394 creator A5012094328 @default.
• W2345731394 creator A5025558024 @default.
• W2345731394 creator A5032470217 @default.
• W2345731394 creator A5089596894 @default.
• W2345731394 date "2016-05-09" @default.
• W2345731394 modified "2023-10-03" @default.
• W2345731394 title "Upregulation of Id3 inhibits cell proliferation and induces apoptosis in A549/DDP human lung cancer cells in vitro" @default.
• W2345731394 cites W1520149501 @default.
• W2345731394 cites W1522139704 @default.
• W2345731394 cites W1587490975 @default.
• W2345731394 cites W1903216121 @default.
• W2345731394 cites W1966203663 @default.
• W2345731394 cites W1971166256 @default.
• W2345731394 cites W1974156902 @default.
• W2345731394 cites W1996879005 @default.
• W2345731394 cites W2010263122 @default.
• W2345731394 cites W2023243097 @default.
• W2345731394 cites W2026199302 @default.
• W2345731394 cites W2068857334 @default.
• W2345731394 cites W208962477 @default.
• W2345731394 cites W2090059791 @default.
• W2345731394 cites W2125164793 @default.
• W2345731394 cites W2125422478 @default.
• W2345731394 cites W2129292492 @default.
• W2345731394 cites W2131489806 @default.
• W2345731394 cites W2137260562 @default.
• W2345731394 cites W2137319489 @default.
• W2345731394 cites W2138648671 @default.
• W2345731394 cites W2144779713 @default.
• W2345731394 cites W2146922312 @default.
• W2345731394 cites W2150262642 @default.
• W2345731394 cites W2159511823 @default.
• W2345731394 cites W2162117433 @default.
• W2345731394 cites W2167759621 @default.
• W2345731394 cites W2211501170 @default.
• W2345731394 doi "https://doi.org/10.3892/mmr.2016.5221" @default.
• W2345731394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27176047" @default.
• W2345731394 hasPublicationYear "2016" @default.
• W2345731394 type Work @default.
• W2345731394 sameAs 2345731394 @default.
• W2345731394 citedByCount "10" @default.
• W2345731394 countsByYear W23457313942017 @default.
• W2345731394 countsByYear W23457313942018 @default.
• W2345731394 countsByYear W23457313942020 @default.
• W2345731394 countsByYear W23457313942021 @default.
• W2345731394 countsByYear W23457313942023 @default.
• W2345731394 crossrefType "journal-article" @default.
• W2345731394 hasAuthorship W2345731394A5011046893 @default.
• W2345731394 hasAuthorship W2345731394A5012094328 @default.
• W2345731394 hasAuthorship W2345731394A5025558024 @default.
• W2345731394 hasAuthorship W2345731394A5032470217 @default.
• W2345731394 hasAuthorship W2345731394A5089596894 @default.
• W2345731394 hasBestOaLocation W23457313941 @default.
• W2345731394 hasConcept C121608353 @default.
• W2345731394 hasConcept C153911025 @default.
• W2345731394 hasConcept C190283241 @default.
• W2345731394 hasConcept C2775934118 @default.
• W2345731394 hasConcept C2780783641 @default.
• W2345731394 hasConcept C2781018059 @default.
• W2345731394 hasConcept C29537977 @default.
• W2345731394 hasConcept C31573885 @default.
• W2345731394 hasConcept C502942594 @default.
• W2345731394 hasConcept C53227056 @default.
• W2345731394 hasConcept C54009773 @default.
• W2345731394 hasConcept C54355233 @default.
• W2345731394 hasConcept C55493867 @default.
• W2345731394 hasConcept C62112901 @default.
• W2345731394 hasConcept C81729549 @default.
• W2345731394 hasConcept C81885089 @default.
• W2345731394 hasConcept C86803240 @default.
• W2345731394 hasConcept C96232424 @default.
• W2345731394 hasConceptScore W2345731394C121608353 @default.
• W2345731394 hasConceptScore W2345731394C153911025 @default.
• W2345731394 hasConceptScore W2345731394C190283241 @default.
• W2345731394 hasConceptScore W2345731394C2775934118 @default.
• W2345731394 hasConceptScore W2345731394C2780783641 @default.
• W2345731394 hasConceptScore W2345731394C2781018059 @default.
• W2345731394 hasConceptScore W2345731394C29537977 @default.
• W2345731394 hasConceptScore W2345731394C31573885 @default.
• W2345731394 hasConceptScore W2345731394C502942594 @default.
• W2345731394 hasConceptScore W2345731394C53227056 @default.
• W2345731394 hasConceptScore W2345731394C54009773 @default.
• W2345731394 hasConceptScore W2345731394C54355233 @default.
• W2345731394 hasConceptScore W2345731394C55493867 @default.
• W2345731394 hasConceptScore W2345731394C62112901 @default.
• W2345731394 hasConceptScore W2345731394C81729549 @default.
• W2345731394 hasConceptScore W2345731394C81885089 @default.
• W2345731394 hasConceptScore W2345731394C86803240 @default.
• W2345731394 hasConceptScore W2345731394C96232424 @default.
• W2345731394 hasIssue "1" @default.
• W2345731394 hasLocation W23457313941 @default.
• W2345731394 hasLocation W23457313942 @default.
• W2345731394 hasOpenAccess W2345731394 @default.
• W2345731394 hasPrimaryLocation W23457313941 @default.
• W2345731394 hasRelatedWork W2348417465 @default.

• next