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• W2345754287 endingPage "457" @default.
• W2345754287 startingPage "446" @default.
• W2345754287 abstract "Studies were carried out to determine the indepen- dent and interactive effects of dietary fat and cholesterol on the regulation of hepatic apoB/E receptor expression and its rela- tionship to hepatic cholesterol concentrations and low density lipoprotein (LDL) particle characteristics. Guinea pigs were fed 15% (w/w) .fat diets (lard, olive oil, or corn oil) with cholesterol levels corresponding to absorbed intakes of 6 (basal), 50, 100, or 200% endogenous cholesterol synthesis. Guinea pigs main- tained stable plasma cholesterol levels until cholesterol intake equaled or exceeded endogenous synthesis (P corn oil, with olive oil being intermediate (P < 0.05). Hepatic membrane apoB/E receptor number (Bmu) decreased as dietary cholesterol increased (P < 0.001) without an independent effect of dietary fat saturation. B,,, values were significantly correlated with plasma LDL cholesterol levels (r = -0.632), and with hepatic free (7 = 0.527) and esterified cholesterol (Y = -0.512) concentrations, which were both in- creased with dietary cholesterol (P < 0.001). significant interac- tions between dietary fat type and cholesterol mediated the ex- tent of hepatic free and esterified cholesterol accumulation. Dietary fat and cholesterol interactions also contributed to changes in LDL particle composition and peak density. a The results of these studies do not support the thesis that dietary cholesterol-mediated suppression of apoB/E receptor expression is ameliorated by intake of polyunsaturated fatty acids. Dietary fat type and cholesterol amount interactively affect hepatic cholesterol concentrations and LDL composition and size, which in part determine plasma LDL cholesterol levels.-Lin, E. C. K., M. L. Fernandez, M. A. Tosca, and D. J. McNamara. Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol. J Lipid Res. 1994. 35: 446-457." @default.
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• W2345754287 date "1994-03-01" @default.
• W2345754287 modified "2023-09-23" @default.
• W2345754287 title "Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol." @default.
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• W2345754287 doi "https://doi.org/10.1016/s0022-2275(20)41195-2" @default.
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