FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345773636> ?p ?o ?g. }

• W2345773636 endingPage "951" @default.
• W2345773636 startingPage "944" @default.
• W2345773636 abstract "<h3>Background</h3> The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. <h3>Methods</h3> We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian medicines agency (AIFA) e-registry. Spasticity assessment by the 0–10 numerical rating scale (NRS) scale is available at baseline, after 1 month of treatment (trial period), and at 3 and 6 months. <h3>Results</h3> A total of 1615 patients were recruited from 30 MS centres across Italy. After one treatment month (trial period), we found 70.5% of patients reaching a ≥20% improvement (initial response, IR) and 28.2% who had already reached a ≥30% improvement (clinically relevant response, CRR), with a mean NRS score reduction of 22.6% (from 7.5 to 5.8). After a multivariate analysis, we found an increased probability to reach IR at the first month among patients with primary and secondary progressive MS, (n=1169, OR 1.4 95% CI 1.04 to 1.9, p=0.025) and among patients with >8 NRS score at baseline (OR 1.8 95% CI 1.3–2.4 p<0.001). During the 6 months observation period, 631(39.5%) patients discontinued treatment. The main reasons for discontinuation were lack of effectiveness (n=375, 26.2%) and/or adverse events (n=268, 18.7%). <h3>Conclusions</h3> Sativex can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs." @default.
• W2345773636 created "2016-06-24" @default.
• W2345773636 creator A5001899447 @default.
• W2345773636 creator A5003814961 @default.
• W2345773636 creator A5008399548 @default.
• W2345773636 creator A5016387762 @default.
• W2345773636 creator A5017126964 @default.
• W2345773636 creator A5018024307 @default.
• W2345773636 creator A5023725739 @default.
• W2345773636 creator A5024524974 @default.
• W2345773636 creator A5024633714 @default.
• W2345773636 creator A5026026352 @default.
• W2345773636 creator A5028598705 @default.
• W2345773636 creator A5034216940 @default.
• W2345773636 creator A5039402091 @default.
• W2345773636 creator A5044701851 @default.
• W2345773636 creator A5046530867 @default.
• W2345773636 creator A5051098918 @default.
• W2345773636 creator A5054428701 @default.
• W2345773636 creator A5058676752 @default.
• W2345773636 creator A5059578809 @default.
• W2345773636 creator A5059668121 @default.
• W2345773636 creator A5063501464 @default.
• W2345773636 creator A5065235825 @default.
• W2345773636 creator A5066467312 @default.
• W2345773636 creator A5071409158 @default.
• W2345773636 creator A5074778566 @default.
• W2345773636 creator A5077005223 @default.
• W2345773636 creator A5077301811 @default.
• W2345773636 creator A5081384901 @default.
• W2345773636 creator A5082323154 @default.
• W2345773636 creator A5083385630 @default.
• W2345773636 creator A5086425939 @default.
• W2345773636 creator A5090823185 @default.
• W2345773636 date "2016-05-09" @default.
• W2345773636 modified "2023-10-05" @default.
• W2345773636 title "Efficacy and safety of cannabinoid oromucosal spray for multiple sclerosis spasticity" @default.
• W2345773636 cites W1181448258 @default.
• W2345773636 cites W1790460690 @default.
• W2345773636 cites W1801725150 @default.
• W2345773636 cites W1911127399 @default.
• W2345773636 cites W1981773361 @default.
• W2345773636 cites W2006295793 @default.
• W2345773636 cites W2028269568 @default.
• W2345773636 cites W2043053000 @default.
• W2345773636 cites W2060715958 @default.
• W2345773636 cites W2065512261 @default.
• W2345773636 cites W2067343268 @default.
• W2345773636 cites W2110690684 @default.
• W2345773636 cites W2120992604 @default.
• W2345773636 cites W2134057375 @default.
• W2345773636 cites W2136571523 @default.
• W2345773636 cites W2142081611 @default.
• W2345773636 cites W2148710677 @default.
• W2345773636 cites W2158699108 @default.
• W2345773636 cites W2168300234 @default.
• W2345773636 doi "https://doi.org/10.1136/jnnp-2015-312591" @default.
• W2345773636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5013116" @default.
• W2345773636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27160523" @default.
• W2345773636 hasPublicationYear "2016" @default.
• W2345773636 type Work @default.
• W2345773636 sameAs 2345773636 @default.
• W2345773636 citedByCount "81" @default.
• W2345773636 countsByYear W23457736362016 @default.
• W2345773636 countsByYear W23457736362017 @default.
• W2345773636 countsByYear W23457736362018 @default.
• W2345773636 countsByYear W23457736362019 @default.
• W2345773636 countsByYear W23457736362020 @default.
• W2345773636 countsByYear W23457736362021 @default.
• W2345773636 countsByYear W23457736362022 @default.
• W2345773636 countsByYear W23457736362023 @default.
• W2345773636 crossrefType "journal-article" @default.
• W2345773636 hasAuthorship W2345773636A5001899447 @default.
• W2345773636 hasAuthorship W2345773636A5003814961 @default.
• W2345773636 hasAuthorship W2345773636A5008399548 @default.
• W2345773636 hasAuthorship W2345773636A5016387762 @default.
• W2345773636 hasAuthorship W2345773636A5017126964 @default.
• W2345773636 hasAuthorship W2345773636A5018024307 @default.
• W2345773636 hasAuthorship W2345773636A5023725739 @default.
• W2345773636 hasAuthorship W2345773636A5024524974 @default.
• W2345773636 hasAuthorship W2345773636A5024633714 @default.
• W2345773636 hasAuthorship W2345773636A5026026352 @default.
• W2345773636 hasAuthorship W2345773636A5028598705 @default.
• W2345773636 hasAuthorship W2345773636A5034216940 @default.
• W2345773636 hasAuthorship W2345773636A5039402091 @default.
• W2345773636 hasAuthorship W2345773636A5044701851 @default.
• W2345773636 hasAuthorship W2345773636A5046530867 @default.
• W2345773636 hasAuthorship W2345773636A5051098918 @default.
• W2345773636 hasAuthorship W2345773636A5054428701 @default.
• W2345773636 hasAuthorship W2345773636A5058676752 @default.
• W2345773636 hasAuthorship W2345773636A5059578809 @default.
• W2345773636 hasAuthorship W2345773636A5059668121 @default.
• W2345773636 hasAuthorship W2345773636A5063501464 @default.
• W2345773636 hasAuthorship W2345773636A5065235825 @default.
• W2345773636 hasAuthorship W2345773636A5066467312 @default.
• W2345773636 hasAuthorship W2345773636A5071409158 @default.
• W2345773636 hasAuthorship W2345773636A5074778566 @default.
• W2345773636 hasAuthorship W2345773636A5077005223 @default.

• next