FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345828978> ?p ?o ?g. }

• W2345828978 endingPage "106" @default.
• W2345828978 startingPage "97" @default.
• W2345828978 abstract "AM-2201 is a popular synthetic cannabinoid first synthesized in 2000. AM-2201 pharmacokinetic and pharmacodynamic data are scarce, requiring further investigation. We developed a sensitive method for quantifying AM-2201 and 13 metabolites in plasma to provide a tool to further metabolic, pharmacokinetic and pharmacodynamic studies. Analysis was performed by liquid chromatography-tandem mass spectrometry. Chromatographic separation was performed by gradient elution on a biphenyl column with 0.1% formic acid in water/0.1% formic acid in acetonitrile:methanol 50:50 (v/v) mobile phase. Sample preparation (75 μL) consisted of an enzymatic hydrolysis and a supported liquid extraction. The method was validated with human plasma with a 0.025 or 0.050–50 μg/L working range, and cross-validated for rat plasma. Analytical recovery was 88.8–110.1% of target concentration, and intra- (n = 30) and inter-day (n = 30) imprecision < 11.9% coefficient of variation. Method recoveries and matrix effects ranged from 58.4–84.4% and −62.1 to −15.6%, respectively. AM-2201 and metabolites were stable (±20%) at room temperature for 24 h, at 4 °C for 72 h, and after three freeze-thaw cycles, and for 72 h in the autosampler after extraction. The method was developed for pharmacodynamic and pharmacokinetic studies with controlled administration in rats but is applicable for pre-clinical and clinical research and forensic investigations. Rat plasma specimen analysis following subcutaneous AM-2201 administration demonstrated the suitability of the method. AM-2201, JWH-018 N-(5-hydroxypentyl), and JWH-018 N-pentanoic acid concentrations were 4.8 ± 1.0, 0.15 ± 0.03, and 0.34 ± 0.07 μg/L, respectively, 8 h after AM-2201 administration at 0.3 mg/kg (n = 5)." @default.
• W2345828978 created "2016-06-24" @default.
• W2345828978 creator A5001384972 @default.
• W2345828978 creator A5004773599 @default.
• W2345828978 creator A5022661574 @default.
• W2345828978 creator A5026069141 @default.
• W2345828978 creator A5047883179 @default.
• W2345828978 creator A5057275199 @default.
• W2345828978 date "2016-06-01" @default.
• W2345828978 modified "2023-09-25" @default.
• W2345828978 title "Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry" @default.
• W2345828978 cites W1536445278 @default.
• W2345828978 cites W1855306715 @default.
• W2345828978 cites W1893134605 @default.
• W2345828978 cites W1968368564 @default.
• W2345828978 cites W1968753875 @default.
• W2345828978 cites W1973544026 @default.
• W2345828978 cites W1980199333 @default.
• W2345828978 cites W1982611995 @default.
• W2345828978 cites W1987155839 @default.
• W2345828978 cites W1990920353 @default.
• W2345828978 cites W2006938395 @default.
• W2345828978 cites W2023741455 @default.
• W2345828978 cites W2024648171 @default.
• W2345828978 cites W2038784126 @default.
• W2345828978 cites W2042625433 @default.
• W2345828978 cites W2048091175 @default.
• W2345828978 cites W2052889127 @default.
• W2345828978 cites W2072475603 @default.
• W2345828978 cites W2073339842 @default.
• W2345828978 cites W2074168161 @default.
• W2345828978 cites W2080448879 @default.
• W2345828978 cites W2111083064 @default.
• W2345828978 cites W2120942096 @default.
• W2345828978 cites W2140768805 @default.
• W2345828978 cites W2148611011 @default.
• W2345828978 cites W2153539777 @default.
• W2345828978 cites W2156324818 @default.
• W2345828978 cites W2187724952 @default.
• W2345828978 cites W4254185355 @default.
• W2345828978 cites W4292464318 @default.
• W2345828978 doi "https://doi.org/10.1016/j.chroma.2016.05.020" @default.
• W2345828978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4886661" @default.
• W2345828978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27208987" @default.
• W2345828978 hasPublicationYear "2016" @default.
• W2345828978 type Work @default.
• W2345828978 sameAs 2345828978 @default.
• W2345828978 citedByCount "6" @default.
• W2345828978 countsByYear W23458289782018 @default.
• W2345828978 countsByYear W23458289782021 @default.
• W2345828978 countsByYear W23458289782022 @default.
• W2345828978 crossrefType "journal-article" @default.
• W2345828978 hasAuthorship W2345828978A5001384972 @default.
• W2345828978 hasAuthorship W2345828978A5004773599 @default.
• W2345828978 hasAuthorship W2345828978A5022661574 @default.
• W2345828978 hasAuthorship W2345828978A5026069141 @default.
• W2345828978 hasAuthorship W2345828978A5047883179 @default.
• W2345828978 hasAuthorship W2345828978A5057275199 @default.
• W2345828978 hasBestOaLocation W23458289782 @default.
• W2345828978 hasConcept C10390740 @default.
• W2345828978 hasConcept C112705442 @default.
• W2345828978 hasConcept C162356407 @default.
• W2345828978 hasConcept C185592680 @default.
• W2345828978 hasConcept C2777379063 @default.
• W2345828978 hasConcept C2777477808 @default.
• W2345828978 hasConcept C31827203 @default.
• W2345828978 hasConcept C43617362 @default.
• W2345828978 hasConcept C4725764 @default.
• W2345828978 hasConcept C55493867 @default.
• W2345828978 hasConcept C64489805 @default.
• W2345828978 hasConcept C71924100 @default.
• W2345828978 hasConcept C98274493 @default.
• W2345828978 hasConceptScore W2345828978C10390740 @default.
• W2345828978 hasConceptScore W2345828978C112705442 @default.
• W2345828978 hasConceptScore W2345828978C162356407 @default.
• W2345828978 hasConceptScore W2345828978C185592680 @default.
• W2345828978 hasConceptScore W2345828978C2777379063 @default.
• W2345828978 hasConceptScore W2345828978C2777477808 @default.
• W2345828978 hasConceptScore W2345828978C31827203 @default.
• W2345828978 hasConceptScore W2345828978C43617362 @default.
• W2345828978 hasConceptScore W2345828978C4725764 @default.
• W2345828978 hasConceptScore W2345828978C55493867 @default.
• W2345828978 hasConceptScore W2345828978C64489805 @default.
• W2345828978 hasConceptScore W2345828978C71924100 @default.
• W2345828978 hasConceptScore W2345828978C98274493 @default.
• W2345828978 hasFunder F4320332161 @default.
• W2345828978 hasFunder F4320337347 @default.
• W2345828978 hasLocation W23458289781 @default.
• W2345828978 hasLocation W23458289782 @default.
• W2345828978 hasLocation W23458289783 @default.
• W2345828978 hasLocation W23458289784 @default.
• W2345828978 hasOpenAccess W2345828978 @default.
• W2345828978 hasPrimaryLocation W23458289781 @default.
• W2345828978 hasRelatedWork W1840357638 @default.
• W2345828978 hasRelatedWork W1965571376 @default.
• W2345828978 hasRelatedWork W1985186853 @default.
• W2345828978 hasRelatedWork W1986005472 @default.
• W2345828978 hasRelatedWork W1998754189 @default.

• next