FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345852181> ?p ?o ?g. }

• W2345852181 endingPage "130" @default.
• W2345852181 startingPage "121" @default.
• W2345852181 abstract "Stress is a major risk factor for substance abuse. Intermittent social defeat stress increases drug self-administration (SA) and elevates brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area (VTA) in rats. Intra-VTA BDNF overexpression enhances social defeat stress-induced cross-sensitization to psychostimulants and induces nucleus accumbens (NAc) ΔFosB expression. Therefore, increased VTA BDNF may mimic or augment the development of drug abuse-related behavior following social stress. To test this hypothesis, adeno-associated virus (AAV) was infused into the VTA to overexpress either GFP alone (control) or GFP + BDNF. Rats were then either handled or exposed to intermittent social defeat stress before beginning cocaine SA training. The SA acquisition and maintenance phases were followed by testing on a progressive ratio (PR) schedule of cocaine reinforcement, and then during a 12-h access “binge” cocaine SA session. BDNF and ΔFosB were quantified postmortem in regions of the mesocorticolimbic circuitry using immunohistochemistry. Social defeat stress increased cocaine intake on a PR schedule, regardless of virus treatment. While stress alone increased intake during the 12-h binge session, socially-defeated rats that received VTA BDNF overexpression exhibited even greater cocaine intake compared to the GFP-stressed group. However, VTA BDNF overexpression alone did not alter binge intake. BDNF expression in the VTA was also positively correlated with total cocaine intake during binge session. VTA BDNF overexpression increased ΔFosB expression in the NAc, but not in the dorsal striatum. Here we demonstrate that VTA BDNF overexpression increases long-access cocaine intake, but only under stressful conditions. Therefore, enhanced VTA-BDNF expression may be a facilitator for stress-induced increases in drug abuse-related behavior specifically under conditions that capture compulsive-like drug intake." @default.
• W2345852181 created "2016-06-24" @default.
• W2345852181 creator A5002025950 @default.
• W2345852181 creator A5003454044 @default.
• W2345852181 creator A5038950433 @default.
• W2345852181 creator A5045697588 @default.
• W2345852181 creator A5048032894 @default.
• W2345852181 creator A5058487085 @default.
• W2345852181 date "2016-10-01" @default.
• W2345852181 modified "2023-10-12" @default.
• W2345852181 title "Overexpression of BDNF in the ventral tegmental area enhances binge cocaine self-administration in rats exposed to repeated social defeat" @default.
• W2345852181 cites W106918987 @default.
• W2345852181 cites W1484136033 @default.
• W2345852181 cites W1487599137 @default.
• W2345852181 cites W1496088120 @default.
• W2345852181 cites W166919779 @default.
• W2345852181 cites W1775274439 @default.
• W2345852181 cites W1968338376 @default.
• W2345852181 cites W1970466931 @default.
• W2345852181 cites W1971263143 @default.
• W2345852181 cites W1980225069 @default.
• W2345852181 cites W1980464927 @default.
• W2345852181 cites W1981654563 @default.
• W2345852181 cites W1982917824 @default.
• W2345852181 cites W1984346427 @default.
• W2345852181 cites W1990650114 @default.
• W2345852181 cites W2000209446 @default.
• W2345852181 cites W2026907794 @default.
• W2345852181 cites W2033646623 @default.
• W2345852181 cites W2035179537 @default.
• W2345852181 cites W2035896027 @default.
• W2345852181 cites W2039232630 @default.
• W2345852181 cites W2043628322 @default.
• W2345852181 cites W2047608515 @default.
• W2345852181 cites W2050042714 @default.
• W2345852181 cites W2051529627 @default.
• W2345852181 cites W2053981588 @default.
• W2345852181 cites W2056186659 @default.
• W2345852181 cites W2057447983 @default.
• W2345852181 cites W2064784067 @default.
• W2345852181 cites W2065858783 @default.
• W2345852181 cites W2068794037 @default.
• W2345852181 cites W2077392553 @default.
• W2345852181 cites W2078316783 @default.
• W2345852181 cites W2079326043 @default.
• W2345852181 cites W2082534552 @default.
• W2345852181 cites W2083045433 @default.
• W2345852181 cites W2084376094 @default.
• W2345852181 cites W2088816381 @default.
• W2345852181 cites W2094056330 @default.
• W2345852181 cites W2111038577 @default.
• W2345852181 cites W2111431369 @default.
• W2345852181 cites W2115742198 @default.
• W2345852181 cites W2119222668 @default.
• W2345852181 cites W2126192628 @default.
• W2345852181 cites W2128472904 @default.
• W2345852181 cites W2130417276 @default.
• W2345852181 cites W2131513655 @default.
• W2345852181 cites W2139476920 @default.
• W2345852181 cites W2147773916 @default.
• W2345852181 cites W2148223197 @default.
• W2345852181 cites W2155401610 @default.
• W2345852181 cites W2159447534 @default.
• W2345852181 cites W2171822179 @default.
• W2345852181 doi "https://doi.org/10.1016/j.neuropharm.2016.04.045" @default.
• W2345852181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4970900" @default.
• W2345852181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27154426" @default.
• W2345852181 hasPublicationYear "2016" @default.
• W2345852181 type Work @default.
• W2345852181 sameAs 2345852181 @default.
• W2345852181 citedByCount "14" @default.
• W2345852181 countsByYear W23458521812016 @default.
• W2345852181 countsByYear W23458521812017 @default.
• W2345852181 countsByYear W23458521812018 @default.
• W2345852181 countsByYear W23458521812019 @default.
• W2345852181 countsByYear W23458521812020 @default.
• W2345852181 countsByYear W23458521812021 @default.
• W2345852181 countsByYear W23458521812023 @default.
• W2345852181 crossrefType "journal-article" @default.
• W2345852181 hasAuthorship W2345852181A5002025950 @default.
• W2345852181 hasAuthorship W2345852181A5003454044 @default.
• W2345852181 hasAuthorship W2345852181A5038950433 @default.
• W2345852181 hasAuthorship W2345852181A5045697588 @default.
• W2345852181 hasAuthorship W2345852181A5048032894 @default.
• W2345852181 hasAuthorship W2345852181A5058487085 @default.
• W2345852181 hasBestOaLocation W23458521812 @default.
• W2345852181 hasConcept C126322002 @default.
• W2345852181 hasConcept C134018914 @default.
• W2345852181 hasConcept C137183658 @default.
• W2345852181 hasConcept C15744967 @default.
• W2345852181 hasConcept C160539049 @default.
• W2345852181 hasConcept C169760540 @default.
• W2345852181 hasConcept C170493617 @default.
• W2345852181 hasConcept C2776552330 @default.
• W2345852181 hasConcept C2776743251 @default.
• W2345852181 hasConcept C2778555786 @default.
• W2345852181 hasConcept C2778790584 @default.
• W2345852181 hasConcept C2779760398 @default.

• next