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• W2345956809 abstract "Metabolomics, in conjunction with more conventional practises of genomics, transcriptomics and proteomics, provides a significant and holistic approach for a better understanding of the behaviour of individual cells. In a single cell, the transcription process produces mRNA which is translated into proteins, and these proteins act as biocatalysts to control metabolite biosynthesis. The study of metabolites in cellular processes is considered as a bridge that closes the gap between genotype and phenotype, and it provides a complete view on the “functionality” of each individual cell. Metabolomics is more reliable in comparison to other single-cell omics studies, as it offers a big picture on the dynamic functionality of a cell. Nevertheless, this technique is also the most problematic to quantify as the metabolome changes rapidly. The metabolome at the level of single cells is a perfect indicator of phenotypic heterogeneity, however, the techniques required to study the metabolome are relatively new. Further research is required to enhance the technique to improve the coverage of the metabolome, faster and accurate identification of metabolites, and to develop rapid non-destructive measurements. Analysis of the metabolome has to contend with the diversity of biomolecules and the grouping of different analytical platforms for complete metabolomics studies especially in single-cells metabolomics. In this chapter, the recent improvements in analytical tools to unravel single-cell metabolomics, as well as their specificity, will be described. This includes the exciting development and expansion of analytical tool technologies in metabolite analysis. These remarkable technological improvements applied to single cells have encountered several intrinsic limitations and challenges, and these major challenges will be discussed alongside the future prospects of single-cell metabolomics in systems biology." @default.
• W2345956809 created "2016-06-24" @default.
• W2345956809 creator A5000526006 @default.
• W2345956809 creator A5078855025 @default.
• W2345956809 date "2016-01-01" @default.
• W2345956809 modified "2023-09-27" @default.
• W2345956809 title "Single-Cell Metabolomics" @default.
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