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- W2345967029 abstract "In this study 10 healthy volunteers received a single oral dose of 25 mg of tiadipone in coated tablets. The levels of drug in plasma sample of each of the healthy volunteers were determined by a reverse phase HPLC technique. The evolution of the plasma levels of tiadipone with time after oral administration follows a single compartment open kinetic model. The absorption process showed wide interindividual differences with a mean value for the lag time of 0.76 +/- 0.28 h. Tiadipone reaches a maximum plasma concentration with a mean value of 386 ng/ml (range 338-498) between 1 and 3 h after administration. The elimination phase of the drug was seen to be monoexponential. The elimination half-life has a mean value of 3.34 +/- 1.16 h, lower than that established for other benzodiazepines in clinical practice." @default.
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- W2345967029 date "1986-09-01" @default.
- W2345967029 modified "2023-09-23" @default.
- W2345967029 title "Pharmacokinetics of tiadipone: a new anxiolytic." @default.
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