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- W2345983602 abstract "Objectives: To compare the safety and effectiveness of vaginal misoprostol v/s combined vaginal misoprostol withestradiol for priming an unfavourable cervix. Methods: Hospital based, randomized study conducted in Lady GoschenHospital, Mangalore. Women were randomly assigned to receive vaginal misoprostol 25μg or vaginal misoprostol 25μg withvaginal estradiol 50μg. Misoprostol alone was repeated every 6h in both groups till the ripening of the cervix. Cervicalevaluation was done using Bishop’s score. A score of < 4 was taken as unfavorable and cervix was considered as ripe whenthe Bishop’s score > 6. End point of the study was till the ripening of the cervix although evaluation was continued tilldelivery to record the first dose of administration to delivery interval, mode of delivery and fetal outcome. Inclusion criteriawere pregnant women at gestational age >37 weeks with unfavourable cervix, cephalic presentation, singleton pregnancy, prelabour rupture of membranes and PIH. Exclusion criteria were Oligohydramnios, IUGR, previous LSCS and Bishop’s scoreis between 4 to 6. Statistical analysis was performed using student t test, independent sample t test, Mann-Whitney U test, χ2test. A p-value of <0.05 was considered significant. Results: Time interval between the administration of the first dose tocervical ripening (p<0.001) and vaginal delivery (p<0.001), number of doses of misoprostol required for cervical ripening(p<0.001), the number of cases of failure of cervical ripening (p=0.009) were found to be lesser in the misoprostol andestradiol group when compared to the misoprostol only group. Conclusion: Estradiol acts synergistically with misoprostolvaginally and significantly hastens the process of cervical ripening, vaginal delivery and also decreases the number of dosesof misoprostol required to achieve this." @default.
- W2345983602 created "2016-06-24" @default.
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- W2345983602 date "2013-01-01" @default.
- W2345983602 modified "2023-09-27" @default.
- W2345983602 title "Induction of labor in unfavourable cervix: vaginal misoprostol versus vaginalmisoprostol with estradiol" @default.
- W2345983602 hasPublicationYear "2013" @default.
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