FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345988176> ?p ?o ?g. }

• W2345988176 endingPage "105" @default.
• W2345988176 startingPage "101" @default.
• W2345988176 abstract "The in vitro activity of the new artemisinin derivative artemisone as well as other molecules of the same class against Helicobacter pylori and their effects when combined with standard antibiotics were evaluated. Since H. pylori can be internalised into gastric epithelial cells, the effects of artemisinin, dihydroartemisinin and artemisone against intracellular H. pylori were also investigated. Bacteriostatic [minimum inhibitory concentration (MIC)] and bactericidal [minimum bactericidal concentration (MBC)] activities were assessed against 24 clinical strains of H. pylori with different antibiotics susceptibilities. Artemisone showed MIC50 and MIC90 values of 0.25 mg/L and 0.5 mg/L, respectively, and an MBC50 value of 0.5 mg/L. Artemisone was synergistic with amoxicillin in 60% of strains, with clarithromycin in 40% and with metronidazole in 20%. There was no interaction between artemisone and omeprazole or bismuth citrate. Against intracellular H. pylori, only dihydroartemisinin at 2× MIC caused a 1 log10 CFU decrease after 18 h and 24 h of incubation. This is the first demonstration in vitro of the activity of artemisinin derivatives against intracellular H. pylori and indicates that artemisone has the potential to be efficacious for the treatment of H. pylori infection, especially in combination with antibiotics." @default.
• W2345988176 created "2016-06-24" @default.
• W2345988176 creator A5007546821 @default.
• W2345988176 creator A5012975973 @default.
• W2345988176 creator A5026196294 @default.
• W2345988176 creator A5046000712 @default.
• W2345988176 creator A5058753868 @default.
• W2345988176 creator A5059519558 @default.
• W2345988176 creator A5064816577 @default.
• W2345988176 creator A5069151660 @default.
• W2345988176 creator A5088081458 @default.
• W2345988176 creator A5089044251 @default.
• W2345988176 date "2016-07-01" @default.
• W2345988176 modified "2023-10-13" @default.
• W2345988176 title "In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori" @default.
• W2345988176 cites W1901292304 @default.
• W2345988176 cites W1986230827 @default.
• W2345988176 cites W2016562927 @default.
• W2345988176 cites W2024703363 @default.
• W2345988176 cites W2033594904 @default.
• W2345988176 cites W2071695336 @default.
• W2345988176 cites W2091079341 @default.
• W2345988176 cites W2095020153 @default.
• W2345988176 cites W2119815059 @default.
• W2345988176 cites W2124614283 @default.
• W2345988176 cites W2125030854 @default.
• W2345988176 cites W2144285906 @default.
• W2345988176 cites W2146144066 @default.
• W2345988176 cites W2148509966 @default.
• W2345988176 cites W2160372995 @default.
• W2345988176 cites W2163187040 @default.
• W2345988176 cites W2281504766 @default.
• W2345988176 doi "https://doi.org/10.1016/j.ijantimicag.2016.03.018" @default.
• W2345988176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27216383" @default.
• W2345988176 hasPublicationYear "2016" @default.
• W2345988176 type Work @default.
• W2345988176 sameAs 2345988176 @default.
• W2345988176 citedByCount "20" @default.
• W2345988176 countsByYear W23459881762017 @default.
• W2345988176 countsByYear W23459881762018 @default.
• W2345988176 countsByYear W23459881762019 @default.
• W2345988176 countsByYear W23459881762020 @default.
• W2345988176 countsByYear W23459881762021 @default.
• W2345988176 countsByYear W23459881762022 @default.
• W2345988176 countsByYear W23459881762023 @default.
• W2345988176 crossrefType "journal-article" @default.
• W2345988176 hasAuthorship W2345988176A5007546821 @default.
• W2345988176 hasAuthorship W2345988176A5012975973 @default.
• W2345988176 hasAuthorship W2345988176A5026196294 @default.
• W2345988176 hasAuthorship W2345988176A5046000712 @default.
• W2345988176 hasAuthorship W2345988176A5058753868 @default.
• W2345988176 hasAuthorship W2345988176A5059519558 @default.
• W2345988176 hasAuthorship W2345988176A5064816577 @default.
• W2345988176 hasAuthorship W2345988176A5069151660 @default.
• W2345988176 hasAuthorship W2345988176A5088081458 @default.
• W2345988176 hasAuthorship W2345988176A5089044251 @default.
• W2345988176 hasConcept C176947019 @default.
• W2345988176 hasConcept C185592680 @default.
• W2345988176 hasConcept C202751555 @default.
• W2345988176 hasConcept C203014093 @default.
• W2345988176 hasConcept C26381139 @default.
• W2345988176 hasConcept C2776120307 @default.
• W2345988176 hasConcept C2776409635 @default.
• W2345988176 hasConcept C2776962512 @default.
• W2345988176 hasConcept C2777498785 @default.
• W2345988176 hasConcept C2778048844 @default.
• W2345988176 hasConcept C2778371730 @default.
• W2345988176 hasConcept C2779708577 @default.
• W2345988176 hasConcept C2781160685 @default.
• W2345988176 hasConcept C501593827 @default.
• W2345988176 hasConcept C54355233 @default.
• W2345988176 hasConcept C55493867 @default.
• W2345988176 hasConcept C79879829 @default.
• W2345988176 hasConcept C86803240 @default.
• W2345988176 hasConcept C89423630 @default.
• W2345988176 hasConcept C98274493 @default.
• W2345988176 hasConceptScore W2345988176C176947019 @default.
• W2345988176 hasConceptScore W2345988176C185592680 @default.
• W2345988176 hasConceptScore W2345988176C202751555 @default.
• W2345988176 hasConceptScore W2345988176C203014093 @default.
• W2345988176 hasConceptScore W2345988176C26381139 @default.
• W2345988176 hasConceptScore W2345988176C2776120307 @default.
• W2345988176 hasConceptScore W2345988176C2776409635 @default.
• W2345988176 hasConceptScore W2345988176C2776962512 @default.
• W2345988176 hasConceptScore W2345988176C2777498785 @default.
• W2345988176 hasConceptScore W2345988176C2778048844 @default.
• W2345988176 hasConceptScore W2345988176C2778371730 @default.
• W2345988176 hasConceptScore W2345988176C2779708577 @default.
• W2345988176 hasConceptScore W2345988176C2781160685 @default.
• W2345988176 hasConceptScore W2345988176C501593827 @default.
• W2345988176 hasConceptScore W2345988176C54355233 @default.
• W2345988176 hasConceptScore W2345988176C55493867 @default.
• W2345988176 hasConceptScore W2345988176C79879829 @default.
• W2345988176 hasConceptScore W2345988176C86803240 @default.
• W2345988176 hasConceptScore W2345988176C89423630 @default.
• W2345988176 hasConceptScore W2345988176C98274493 @default.
• W2345988176 hasFunder F4320320672 @default.
• W2345988176 hasIssue "1" @default.

• next