FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2345998992> ?p ?o ?g. }

• W2345998992 endingPage "994" @default.
• W2345998992 startingPage "984" @default.
• W2345998992 abstract "The melanocortin system has been implicated in the regulation of various physiological functions including melanogenesis, steroidogenesis, energy homeostasis, and feeding behavior. Five melanocortin receptors have been identified to date and belong to the family of G protein-coupled receptors (GPCR). Post-translational modification of the proopiomelanocortin (POMC) prohormone leads to the biosynthesis of the endogenous melanocortin agonists, including α-melanocyte stimulating hormone (α-MSH), β-MSH, γ-MSH, and adrenocorticotropic hormone (ACTH). All the melanocortin agonists derived from the POMC prohormone contain a His-Phe-Arg-Trp tetrapeptide sequence that has been implicated in eliciting the pharmacological responses at the melanocortin receptors. Herein, an alanine (Ala) positional scan is reported for the endogenous α-MSH ligand and the synthetic, more potent, NDP-MSH peptide (Ac-Ser1-Tyr2-Ser3-Nle4-Glu5-His6-DPhe7-Arg8-Trp9-Gly10-Lys11-Pro12-Val13-NH2) at the cloned mouse melanocortin receptors to test the assumption that the structure–activity relationships of one ligand would apply to the other. Several residues outside of the postulated pharmacophore altered potency at the melanocortin receptors, most notably the 1560-, 37-, and 15-fold potency loss when the Glu5 position of α-MSH was substituted with Ala at the mMC1R, mMC3R, and mMC4R, respectively. Importantly, the altered potencies due to Ala substitutions in α-MSH did not necessarily correlate with equivalent Ala substitutions in NDP-MSH, indicating that structural modifications and corresponding biological activities in one of these melanocortin ligands may not be predictive for the other agonist." @default.
• W2345998992 created "2016-06-24" @default.
• W2345998992 creator A5005986173 @default.
• W2345998992 creator A5016981335 @default.
• W2345998992 creator A5057207286 @default.
• W2345998992 creator A5062540705 @default.
• W2345998992 creator A5079951345 @default.
• W2345998992 creator A5087425726 @default.
• W2345998992 creator A5087487462 @default.
• W2345998992 date "2016-05-17" @default.
• W2345998992 modified "2023-10-18" @default.
• W2345998992 title "Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure–Activity Relationships at the Mouse Melanocortin Receptors" @default.
• W2345998992 cites W1488596761 @default.
• W2345998992 cites W1545949007 @default.
• W2345998992 cites W1549372716 @default.
• W2345998992 cites W1566308385 @default.
• W2345998992 cites W171555081 @default.
• W2345998992 cites W1754455313 @default.
• W2345998992 cites W1964488668 @default.
• W2345998992 cites W1970716955 @default.
• W2345998992 cites W1971172729 @default.
• W2345998992 cites W1971926475 @default.
• W2345998992 cites W1975055733 @default.
• W2345998992 cites W1975149833 @default.
• W2345998992 cites W1979420492 @default.
• W2345998992 cites W1979980861 @default.
• W2345998992 cites W1990332976 @default.
• W2345998992 cites W1990472503 @default.
• W2345998992 cites W1990492207 @default.
• W2345998992 cites W1990572454 @default.
• W2345998992 cites W1991782778 @default.
• W2345998992 cites W2001113617 @default.
• W2345998992 cites W2007214349 @default.
• W2345998992 cites W2007269300 @default.
• W2345998992 cites W2007707212 @default.
• W2345998992 cites W2008782354 @default.
• W2345998992 cites W2010142606 @default.
• W2345998992 cites W2013073212 @default.
• W2345998992 cites W2015986042 @default.
• W2345998992 cites W2020624821 @default.
• W2345998992 cites W2022291462 @default.
• W2345998992 cites W2026135031 @default.
• W2345998992 cites W2027347113 @default.
• W2345998992 cites W2028115617 @default.
• W2345998992 cites W2037447899 @default.
• W2345998992 cites W2039609369 @default.
• W2345998992 cites W2042655455 @default.
• W2345998992 cites W2042658226 @default.
• W2345998992 cites W2045664576 @default.
• W2345998992 cites W2055429514 @default.
• W2345998992 cites W2056373428 @default.
• W2345998992 cites W2058815815 @default.
• W2345998992 cites W2066848914 @default.
• W2345998992 cites W2067286729 @default.
• W2345998992 cites W2068508492 @default.
• W2345998992 cites W2081232278 @default.
• W2345998992 cites W2083116048 @default.
• W2345998992 cites W2084677170 @default.
• W2345998992 cites W2087328208 @default.
• W2345998992 cites W2089018293 @default.
• W2345998992 cites W2090460315 @default.
• W2345998992 cites W2090565260 @default.
• W2345998992 cites W2090681821 @default.
• W2345998992 cites W2091663002 @default.
• W2345998992 cites W2094828639 @default.
• W2345998992 cites W2095417482 @default.
• W2345998992 cites W2098181391 @default.
• W2345998992 cites W2105470099 @default.
• W2345998992 cites W2124259633 @default.
• W2345998992 cites W2138563371 @default.
• W2345998992 cites W2144969564 @default.
• W2345998992 cites W2265698540 @default.
• W2345998992 cites W2327873316 @default.
• W2345998992 cites W2413506533 @default.
• W2345998992 cites W2416890084 @default.
• W2345998992 cites W4243151626 @default.
• W2345998992 cites W4247774284 @default.
• W2345998992 doi "https://doi.org/10.1021/acschemneuro.6b00098" @default.
• W2345998992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5596636" @default.
• W2345998992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27135265" @default.
• W2345998992 hasPublicationYear "2016" @default.
• W2345998992 type Work @default.
• W2345998992 sameAs 2345998992 @default.
• W2345998992 citedByCount "5" @default.
• W2345998992 countsByYear W23459989922017 @default.
• W2345998992 countsByYear W23459989922019 @default.
• W2345998992 countsByYear W23459989922021 @default.
• W2345998992 countsByYear W23459989922023 @default.
• W2345998992 crossrefType "journal-article" @default.
• W2345998992 hasAuthorship W2345998992A5005986173 @default.
• W2345998992 hasAuthorship W2345998992A5016981335 @default.
• W2345998992 hasAuthorship W2345998992A5057207286 @default.
• W2345998992 hasAuthorship W2345998992A5062540705 @default.
• W2345998992 hasAuthorship W2345998992A5079951345 @default.
• W2345998992 hasAuthorship W2345998992A5087425726 @default.
• W2345998992 hasAuthorship W2345998992A5087487462 @default.
• W2345998992 hasBestOaLocation W23459989922 @default.
• W2345998992 hasConcept C104317684 @default.

• next